biological source
mouse
Quality Level
antibody form
purified antibody
antibody product type
primary antibodies
clone
monoclonal
species reactivity
rat, mouse, bovine, human
manufacturer/tradename
Upstate®
technique(s)
immunoprecipitation (IP): suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... PLCB1(23236)
Specificity
PLCβ-1, also recognize the 100kDa and 41kDa fragments of PLCβ-1.1
Immunogen
Mixed monoclonal antibodies raised against purified bovine PLCβ-1
Application
Detect PLCβ-1 using this Anti-PLCβ-1 Antibody validated for use in IP.
Research Category
Signaling
Signaling
Research Sub Category
Lipid Signaling
Lipid Signaling
Quality
routinely evaluated by immunoprecipition of PLCβ-1 from a bovine brain membrane preparation, subsequent immunoblotting performed by the antibody
Target description
150 kDa
Physical form
100mM Tris-glycine, pH 7.4, 0.15M NaCl with 0.05% sodium azide
Format: Purified
Protein G Chromatography
Storage and Stability
2 years at -20°C
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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N Liu et al.
The Journal of biological chemistry, 271(1), 355-360 (1996-01-05)
To discover a new phospholipase C (PLC) related to cell growth, we screened a cDNA library prepared from regenerating rat liver. A novel PLC (PLC delta 4) encoding a polypeptide of 770 amino acids with structural similarity to PLC delta-type
Roberta Fiume et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 23(3), 957-966 (2008-11-26)
Inositide-specific phospholipase Cbeta1 (PLCbeta1) signaling in cell proliferation has been investigated thoroughly in the G(1) cell cycle phase. However, little is known about its involvement in G(2)/M progression. We used murine erythroleukemia cells to investigate the role of PLCbeta1 in
Hideki Igarashi et al.
Developmental biology, 312(1), 321-330 (2007-10-27)
Inositol 1,4,5-trisphosphate generated by the action of a phospholipase C (PLC) mediates release of intracellular Ca2+ that is essential for sperm-induced activation of mammalian eggs. Much attention currently focuses on the role of sperm-derived PLCzeta in generating changes in egg
Three prime exonuclease I (TREX1) is Fos/AP-1 regulated by genotoxic stress and protects against ultraviolet light and benzo(a)pyrene-induced DNA damage.
Christmann, M; Tomicic, MT; Aasland, D; Berdelle, N; Kaina, B
Nucleic Acids Research null
P Sánchez-Blázquez et al.
The Journal of pharmacology and experimental therapeutics, 285(2), 820-827 (1998-05-15)
To analyze the selectivity of delta receptor subtypes to regulate different classes of G proteins, the expression of the alpha-subunits of Gi2, Gi3, Go1, Go2, Gq and G11 transducer proteins was reduced by administration of oligodeoxynucleotides (ODNs) complementary to sequences
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