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04-638

Sigma-Aldrich

Anti-TRF1 Antibody, clone BED5 57-6

clone BED5 57-6, Upstate®, from mouse

Synonym(s):

TERF1, telomeric repeat binding factor (NIMA-interacting) 1, FLJ41416, PIN2, TRBF1, TRF, TRF1, hTRF1-AS, t-TRF1

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

clone

BED5 57-6, monoclonal

species reactivity

mouse, rat, hamster, monkey, human

packaging

antibody small pack of 25 μg

manufacturer/tradename

Upstate®

technique(s)

immunofluorescence: suitable
western blot: suitable

isotype

IgG1κ

NCBI accession no.

NP_059523

UniProt accession no.

P54274

shipped in

ambient

target post-translational modification

unmodified

Gene Information

human ... TERF1(7013)

Specificity

Detects TRF1

Immunogen

Human TRF1 protein

Application

This Anti-TRF1 Antibody, clone BED5 57-6 is validated for use in WB, IF for the detection of TRF1.

Quality

Routinely evaluated by Western Blot on HeLa cell lysate.

Target description

~60 kDa

Physical form

Affinity purified immunoglobulin in PBS with 0.05% NaN3
Format: Purified

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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Certificates of Analysis (COA)

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PTOP and TRF1 help enhance the radio resistance in breast cancer cell.
Li, Z; Yang, X; Xia, N; Yang, L; Yu, H; Zhou, F; X, C; Zhou, Y
Cancer Cell International null
Emily Mason-Osann et al.
EMBO reports, 21(6), e49495-e49495 (2020-04-28)
Cancer cells can activate the alternative lengthening of telomeres (ALT) pathway to promote replicative immortality. The ALT pathway promotes telomere elongation through a homologous recombination pathway known as break-induced replication (BIR), which is often engaged to repair single-ended double-stranded breaks

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