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399000

Sigma-Aldrich

2,2,2-Trifluoroethyl butyrate

98%

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About This Item

Linear Formula:
CH3CH2CH2COOCH2CF3
CAS Number:
371-27-7
Molecular Weight:
170.13
Beilstein:
1769212
MDL number:
MFCD00077609
UNSPSC Code:
12352100
PubChem Substance ID:
24864780

Assay

98%

refractive index

n20/D 1.347 (lit.)

bp

113 °C/747 mmHg (lit.)

density

1.127 g/mL at 25 °C (lit.)

SMILES string

CCCC(=O)OCC(F)(F)F

InChI

1S/C6H9F3O2/c1-2-3-5(10)11-4-6(7,8)9/h2-4H2,1H3

InChI key

DEXWRCYOMLUJRF-UHFFFAOYSA-N

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General description

Solvent effects on porcine pancreatic lipase-catalyzed transesterification of 2,2,2-trifluoroethyl butyrate has been studied. Kinetics of the reaction of OH radicals and Cl atoms with 2,2,2 trifluoroethyl butyrate has been reported.

Application

2,2,2-Trifluoroethyl butyrate may be used in the lipase catalyzed resolution of unsubstituted and N-alkyl substituted 2-amino-1-phenylethanols. It may be used in the synthesis of enantiomerically pure (R)- or (S)-1-aminoindane.

Pictograms

FlameExclamation mark
GHS02,GHS07

Signal Word

Danger

Hazard Statements

H225,H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point(F)

69.8 °F - closed cup

Flash Point(C)

21 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Tropospheric degradation of 2, 2, 2 trifluoroethyl butyrate: Kinetic study of their reactions with OH radicals and Cl atoms at 298K.
Blanco MB, et al.
Chemical Physics Letters, 578, 33-37 (2013)
Lipase catalysis in the optical resolution of 2-amino-1-phenylethanol derivatives.
Kanerva LT, et al.
Journal of the Chemical Society. Perkin Transactions 1, 14, 1759-1762 (1992)
W H Boesten et al.
Organic letters, 3(8), 1121-1124 (2001-05-12)
[reaction: see text]. Diastereoselective Strecker reactions based on (R)-phenylglycine amide as chiral auxiliary are reported. The Strecker reaction is accompanied by an in situ crystallization-induced asymmetric transformation, whereby one diastereomer selectively precipitates and can be isolated in 76-93% yield and
L T Kanerva et al.
Acta chemica Scandinavica (Copenhagen, Denmark : 1989), 44(10), 1032-1035 (1990-11-01)
Porcine pancreatic lipase-catalysed transesterifications of 2,2,2-trifluoroethyl butyrate with racemic 2-octanol and 1-phenylethanol have been studied in different organic solvents. Solvent hydrophobicity (log P -1.1 to 3.3) has only a minor effect on the reaction rate. Independently of the solvent used

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