NUDT1
nudix (nucleoside diphosphate linked moiety X)-type motif 1
Synonyms:
MTH1
Species:
Human NUDT1 (4521), Mouse Nudt1 (17766), Rat Nudt1 (117260), dog NUDT1 (489894), Zebrafish nudt1 (406727), chicken NUDT1 (416467), domestic guinea pig Nudt1 (100730917), naked mole-rat Nudt1 (101712324), domestic cat NUDT1 (101091068), cow NUDT1 (525496)
UniProtKB ID:
Gene ID:
- Human(4521) Summary: Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described. [provided by RefSeq, Jul 2008]
- Mouse(17766) nudix (nucleoside diphosphate linked moiety X)-type motif 1
- Rat(117260) nudix (nucleoside diphosphate linked moiety X)-type motif 1
- dog(489894) nudix (nucleoside diphosphate linked moiety X)-type motif 1
- Zebrafish(406727) nudix (nucleoside diphosphate linked moiety X)-type motif 1
- chicken(416467) nudix (nucleoside diphosphate linked moiety X)-type motif 1
- domestic guinea pig(100730917) nudix (nucleoside diphosphate linked moiety X)-type motif 1
- naked mole-rat(101712324) nudix (nucleoside diphosphate linked moiety X)-type motif 1
- domestic cat(101091068) nudix (nucleoside diphosphate linked moiety X)-type motif 1
- cow(525496) nudix (nucleoside diphosphate linked moiety X)-type motif 1
- sheep(101119103) nudix (nucleoside diphosphate linked moiety X)-type motif 1
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-MTH1 Antibody, clone 0P6T10, Rabbit Monoclonal, ,
Species Reactivity
human
Application
western blot
Anti-NUDT1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-NUDT1 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Anti-NUDT1 antibody produced in rabbit, ,
Species Reactivity
human
Application
immunohistochemistry
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Anti-MTH1 Antibody, clone 11A3.2, clone 11A3.2, from mouse,
Species Reactivity
human
Application
western blot