T6764

Triprolidine hydrochloride

≥99%, H1 histamine receptor antagonist

• Synonym(s): (E)-2-[3-(1-Pyrrolidinyl)-1-p-tolylpropenyl]pyridine hydrochloride, trans-2-[3-(1-Pyrrolidinyl)-1-p-tolylpropenyl]pyridine hydrochloride
• Empirical Formula (Hill Notation): C₁₉H₂₂N₂ · HCl
• CAS Number: 6138-79-0
• Molecular Weight: 314.85
• UNSPSC Code: 12352200
• PubChem Substance ID: 24277808
• NACRES: NA.77
• MDL number: MFCD00039044
• Assay: ≥99%

Properties

• Product Name: Triprolidine hydrochloride, ≥99%
• Quality Segment: 200
• assay: ≥99%
• solubility: alcohol: soluble 1 in 1.5 of solvent, chloroform: soluble 1 in less than 1 of solvent, H₂O: soluble 50 mg/mL, clear, colorless to yellow
• originator: GlaxoSmithKline
• storage temp.: 2-8°C
• SMILES string: CC(C=C1)=CC=C1/C(C2=NC=CC=C2)=C\CN3CCCC3.Cl
• InChI: 1S/C19H22N2.ClH/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21;/h2-3,6-12H,4-5,13-15H2,1H3;1H/b18-11+;
• InChI key: WYUYEJNGHIOFOC-NWBUNABESA-N
• Gene Information: human ... HRH1(3269)

Description

Application

Triprolidine has been used as a H1 histaminergic inhibitor to study its effect on long-term potentiation (LTP) in tuberomammillary nucleus (TMN) neurons.

Biochem/physiol Actions

H₁ histamine receptor antagonist.

Features and Benefits

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Preparation Note

Triprolidine hydrochloride is soluble in water at 50 mg/ml and yields a clear, colorless to yellow solution. It is also soluble in alcohol (1 in 1.5 of solvent) and chloroform (1 in less than 1 of solvent).

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Codes: H302,H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• PPE (personal protective equipment): dust mask type N95 (US), Eyeshields, Gloves