SML2018

GSK4027

≥98% (HPLC)

• Synonym(s): 4-Bromo-2-methyl-5-(((3R,5R)-1-methyl-5-phenylpiperidin-3-yl)-amino)pyridazin-3(2H)-one, 4-Bromo-2-methyl-5-[[(3R,5R)-1-methyl-5-phenyl-3-piperidinyl]amino]-3(2H)-pyridazinone
• Empirical Formula (Hill Notation): C₁₇H₂₁BrN₄O
• CAS Number: 2079896-25-4
• Molecular Weight: 377.28
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: −20°C
• SMILES string: CN(C[C@H](C1)C2=CC=CC=C2)C[C@@H]1NC(C=NN(C3=O)C)=C3Br
• InChI: 1S/C17H21BrN4O/c1-21-10-13(12-6-4-3-5-7-12)8-14(11-21)20-15-9-19-22(2)17(23)16(15)18/h3-7,9,13-14,20H,8,10-11H2,1-2H3/t13-,14+/m0/s1
• InChI key: VZAFGXCWAWRULT-UONOGXRCSA-N

Description

Biochem/physiol Actions

GSK4027 is a cell penetrant, potent and selective inhibitor of PCAF/GCN5 bromodomain [p300/CBP-associated factor (PCAF)/general control nonderepressible 5 (GCN5) bromodomain].

It acts as a chemical probe for PCAF/GCN5.

cell penetrant, potent and selective inhibitor of PCAF/GCN5 bromodomain

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable