SML0844

GNF 5837

≥98% (HPLC)

• Synonym(s): N-[3-[[2,3-Dihydro-2-oxo-3-(1H-pyrrol-2-ylmethylene)-1H-indol-6-yl]amino]-4-methylphenyl]-N′-[2-fluoro-5-(trifluoromethyl)phenyl]-urea
• Empirical Formula (Hill Notation): C₂₈H₂₁F₄N₅O₂
• CAS Number: 1033769-28-6
• Molecular Weight: 535.49
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: yellow to orange
• solubility: DMSO: 5 mg/mL, clear (warmed)
• storage temp.: 2-8°C
• SMILES string: FC(F)(F)c1cc(c(cc1)F)NC(=O)Nc2cc(c(cc2)C)Nc3cc4c(cc3)\C(=C\c5[nH]ccc5)\C(=O)N4
• InChI: 1S/C28H21F4N5O2/c1-15-4-6-19(35-27(39)37-25-11-16(28(30,31)32)5-9-22(25)29)13-23(15)34-18-7-8-20-21(12-17-3-2-10-33-17)26(38)36-24(20)14-18/h2-14,33-34H,1H3,(H,36,38)(H2,35,37,39)/b21-12-
• InChI key: YYDUWLSETXNJJT-MTJSOVHGSA-N

Description

Biochem/physiol Actions

GNF-5837 is a selective Trk inhibitor.

GNF-5837 is an orally bioavailable Trk inhibitor (IC₅₀ = 8 and 12 nM for TrkA and TrkB, respectively). GNF-5837 inhibits growth of Ba/F3 cells expressing Tel-Trl fusions. IC₅₀ values for growth inhibition are Tel-TrkA = 11 nM, Tel-TrkB = 9 nM and Tel-TrkC = 7 nM.

Features and Benefits

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Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable