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SML0283

Amorolfine hydrochloride

≥98% (HPLC), Ergosterol biosynthesis inhibitor, powder

Synonym(s):

(2R,6S)-rel-4-[3-[4-(1,1-Dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethyl-morpholine hydrochloride, Ro 14-4767/002

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About This Item

Empirical Formula (Hill Notation):
C21H35ON · HCl
CAS Number:
Molecular Weight:
353.97
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated
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Product Name

Amorolfine hydrochloride, ≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: ≥5 mg/mL (warmed)

storage temp.

room temp

SMILES string

Cl.CCC(C)(C)c1ccc(CC(C)CN2C[C@H](C)O[C@H](C)C2)cc1

InChI

1S/C21H35NO.ClH/c1-7-21(5,6)20-10-8-19(9-11-20)12-16(2)13-22-14-17(3)23-18(4)15-22;/h8-11,16-18H,7,12-15H2,1-6H3;1H/t16?,17-,18+;

InChI key

XZKWIPVTHGWDCF-KUZYQSSXSA-N

Application

Amorolfine hydrochloride has been used as an antifungal agent.

Biochem/physiol Actions

Amorolfine blocks ergosterol biosynthesis by interfering with delta 14 reduction and the delta 7-8 isomerisation.
Amorolfine is a broad-based antifungal agent with fungicidal effects against most fungi, dermatophytes and yeasts.
Amorolfine hydrochloride is a potential for treating onychomycosis infected nails by topical application. A 5% solution combination with fluconazole is effective on sensitive fungus in fingernail onychomycosis.

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This Item
Y0001795Y0001794SML0369
form

powder

form

-

form

-

form

powder

assay

≥98% (HPLC)

assay

-

assay

-

assay

≥98% (HPLC)

Quality Level

100

Quality Level

-

Quality Level

-

Quality Level

100

storage temp.

room temp

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

room temp

storage condition

desiccated

storage condition

-

storage condition

-

storage condition

-

solubility

DMSO: ≥5 mg/mL (warmed)

solubility

-

solubility

-

solubility

DMSO: 10 mg/mL (clear solution)


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Warning

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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