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Key Documents

SCP0200

Sigma-Aldrich

Neuromedin N

Synonym(s):

NMN-125, NN, NT/N, NmN

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About This Item

Empirical Formula (Hill Notation):
C38H63N7O8
Molecular Weight:
745.95
UNSPSC Code:
12352200
NACRES:
NA.32

Assay

≥95% (HPLC)

form

lyophilized

composition

Peptide Content, ≥65%

storage condition

protect from light

UniProt accession no.

P30990

storage temp.

−20°C

Gene Information

human ... NTS(4922)

Amino Acid Sequence

Lys-Ile-Pro-Tyr-Ile-Leu

Biochem/physiol Actions

Neuromedin N is a hexapeptide that is related to neurotensin. Its precursor, proneuromedin N, is expressed in the adrenals, brain, gut and also in several cancers. In myoelectric activity, it has been reported to act in a similar manner as neurotensin, at a lesser degree of potency. Neuromedin N has been shown to increase the chemotaxis capacity of mouse lymphocytes and to modulate function of the hypothalamo-pituitary-adrenocortical axis in rats. Neuromedin N has been proposed to exert its actions via increase in intracellular Ca2+ concentration, although this is uncertain.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Investigation of proNT/NMN secretion from small cell lung carcinoma cells using a mouse xenograft model.
Wakabayashi-Nakao K
Oncology Reports, 28(4), 1181-1186 (2012)
I Schultz et al.
Regulatory peptides, 35(3), 197-205 (1991-09-03)
The effects of neuromedin-N on migrating myoelectric complexes in the small intestine of rats were studied. As neuromedin-N and neurotensin are structurally related peptides a comparison with neurotensin was made. Myoelectric activity was recorded by means of three bipolar electrodes
L K Malendowicz et al.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 47(1), 41-45 (1995-01-01)
The effects of a subcutaneous bolus injection of 2 micrograms neurotensin (NT) or neuromedin N (NMN) on the function of the hypothalamo-pituitary-adrenocortical axis were investigated in both normal and cold-stressed rats. The blood concentrations of ACTH, corticosterone (B) and aldosterone
Neuromedin N: high affinity interaction with brain neurotensin receptors and rapid inactivation by brain synaptic peptidases.
Checler F
European Journal of Pharmacology, 126(3), 239-244 (1986)
J J Garrido et al.
Regulatory peptides, 41(1), 27-37 (1992-09-03)
The action of neurotensin and related peptides has not been yet studied on lymphocytes, although there are studies indicating the stimulative action of neurotensin, a peptide first isolated from bovine hypothalamus, on different functions of phagocytic immune cells. The present
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