This product may be stored in room temperature.
F132
Fluoxetine hydrochloride
≥98% (TLC), solid, selective serotonin reuptake inhibitor
Synonym(s):
Fluoxetine HCl, (±)-N-Methyl-γ-[4-(trifluoromethyl)phenoxy]benzenepropanamine hydrochloride, LY-110,140 hydrochloride, Prozac®
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About This Item
Empirical Formula (Hill Notation):
C17H18F3NO · HCl
CAS Number:
Molecular Weight:
345.79
EC Number:
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Pricing and availability is not currently available.
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Product Name
Fluoxetine hydrochloride, solid
form
solid
Quality Level
color
white
solubility
H2O: 4 mg/mL
DMSO: >5 mg/mL
originator
Eli Lilly
SMILES string
CNCCC(C1=CC=CC=C1)OC2=CC=C(C(F)(F)F)C=C2.[H]Cl
InChI
1S/C17H18F3NO.ClH/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20;/h2-10,16,21H,11-12H2,1H3;1H
InChI key
GIYXAJPCNFJEHY-UHFFFAOYSA-N
Gene Information
human ... HTR1A(3350) , HTR1B(3351) , HTR1D(3352) , HTR1E(3354) , HTR1F(3355) , HTR2A(3356) , HTR2B(3357) , HTR2C(3358) , HTR3A(3359) , HTR3B(9177) , HTR3C(170572) , HTR3D(200909) , HTR3E(285242) , HTR4(3360) , HTR5A(3361) , HTR5B(645694) , HTR6(3362) , HTR7(3363) , SLC6A4(6532)
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General description
Application
Fluoxetine hydrochloride has been used to study its effect on the binding ability of the radiopharmaceutical 123I-labeled 2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine ([123I]ADAM) to SERT (serotonin transporters) in mice.[2] It has also been used for the chronic treatment of light deprived animals.[3]It has also been used as a serotonin reuptake inhibitor to study its effects on acute stress in fish.[4]
Biochem/physiol Actions
Fluoxetine hydrochloride works at presynaptic terminals where it prevents the reuptake of serotonin, resulting in the accumulation of serotonin in extracellular fluid at synapses.[2]
Selective serotonin reuptake inhibitor; antidepressant.
Features and Benefits
This compound is a featured product for ADME Tox and Neuroscience research. Discover more featured ADME Tox and Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Biogenic Amine Transporters and Chloride Channels pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Legal Information
Sold under license from Eli Lilly and Company.
Prozac is a registered trademark of Eli Lilly and Co.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - STOT RE 2 - STOT SE 3
Target Organs
Central nervous system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Chromatograms
application for HPLCsuitable for GC-
What is the storage condition once I receive it?
1 answer-
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What is the solubility of item F132, Fluoxetine hydrochloride? Also, how should stock solutions be stored after reconstitution?
1 answer-
The solubility of Fluoxetine hydrochloride is as follows:
• Soluble in water: 3.46 mg/mL
•Soluble in DMSO: 34.58 ng/mL.After reconstitution, it is recommended to store stock solutions in tightly sealed vials at -20°C or below and to use them within 1 month.
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Good day, I wanted to know if buying the 10 mg fluoxetine product would mean the customer would receive a pack of multiple 10 mg fluoxetine pills or if it means the product would just be 10 mg of the drug. Any information will be appreciated. Thank you.
1 answer-
This product is in powder form and is intended for research use only. It is not suitable for any other purpose, which includes, but is not limited to, unauthorized commercial use, in vitro diagnostic use, or therapeutic use in humans or animals.
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