Key Documents

View All Documentation

β-Estradiol 17-valerate

Name: &#946;-Estradiol 17-valerate
Brand: SIGMA

≥98% (HPLC), powder

Synonym(s):

1,3,5(10)-Estratriene-3,17β-diol 17-pentanote

Select a Size

Change View

Pack Size	SKU	Availability	Price

About This Item

Empirical Formula (Hill Notation):

C₂₃H₃₂O₃

CAS Number:

979-32-8

Molecular Weight:

356.50

NACRES:

NA.77

PubChem Substance ID:

24894423

UNSPSC Code:

41116107

EC Number:

213-559-2

MDL number:

MFCD00056541

Beilstein/REAXYS Number:

2480357

Assay:

≥98%

Form:

powder

Quality level:

100

Pricing and availability is not currently available.

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Properties

Product Name

β-Estradiol 17-valerate, ≥98%

biological source

synthetic

Quality Level

100

assay

≥98%

form

powder

technique(s)

ELISA: suitable

solubility

acetone: 25 mg/mL, hazy, colorless

shipped in

ambient

storage temp.

room temp

SMILES string

CCCCC(=O)OC1CCC2C3CCc4cc(O)ccc4C3CCC12C

InChI

1S/C23H32O3/c1-3-4-5-22(25)26-21-11-10-20-19-8-6-15-14-16(24)7-9-17(15)18(19)12-13-23(20,21)2/h7,9,14,18-21,24H,3-6,8,10-13H2,1-2H3

InChI key

RSEPBGGWRJCQGY-UHFFFAOYSA-N

Description

General description

β-Estradiol 17-valerate is a synthetic estrogen.[1]

Application

β-Estradiol 17-valerate has been used:

in an in-vivo assay, to synchronize the estrus cycle in athymic nude mice, to study the effect of recombinant pigment epithelium-derived factor (rPEDF) on induced ectopic fibroid lesions[2]
to study the influence of ovarian hormones on type II cGMP-dependent protein kinase (Prkg2) expression in mice[3]
to induce growth of estrogen-dependent tumor cells in athymic nude mice to establish a breast cancer mouse model[4]

Biochem/physiol Actions

Estradiol valerate is observed to be useful for treating menopausal climacteric symptoms.[5] β-Estradiol 17-valerate is used as a source of 17β-estradiol (E2) in in vitro fertilization, hormone replacement therapy, contraceptive drugs, to study reproductive disorders in animal models.[1] It serves as growth promoter in animal farming. β-Estradiol 17-valerate is also used to culture single-sex population among fish. Studies in rats show that β-Estradiol 17-valerate has negative effects on the estrus cycle pattern.[1]

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item	E8750	K1001	E7879
Sigma-Aldrich E1631 β-Estradiol 17-valerate	Sigma-Aldrich E8750 α-Estradiol	Sigma-Aldrich K1001 β-Estradiol-6-one	Sigma-Aldrich E7879 β-Estradiol 17-acetate
assay ≥98%	assay ≥98% (TLC)	assay ≥98.00% (TLC)	assay ≥99%
form powder	form powder	form powder	form powder
technique(s) ELISA: suitable	technique(s) -	technique(s) -	technique(s) -
Quality Level 100	Quality Level 200	Quality Level 200	Quality Level 200
storage temp. room temp	storage temp. room temp	storage temp. room temp	storage temp. room temp
solubility acetone: 25 mg/mL, hazy, colorless	solubility ethanol: 50 mg/mL, clear, colorless	solubility chloroform: methanol (1:1): 19.60-20.40 mg/mL, clear, colorless to faintly yellow	solubility chloroform: 50 mg/mL, clear, colorless to faintly brownish-yellow

pictograms

GHS08,GHS09

signalword

Warning

hcodes

H351,H361fd,H362,H410

pcodes

P201 - P202 - P260 - P263 - P273 - P308 + P313

Hazard Classifications

Aquatic Chronic 1 - Carc. 2 - Lact. - Repr. 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Prolonged in vivo expression and anti-tumor response of DNA-based anti-HER2 antibodies.

Kevin Hollevoet et al.

Oncotarget, 9(17), 13623-13636 (2018-03-24)

Antibody gene transfer presents an appealing alternative to conventional antibody protein therapy. This pre-clinical study evaluates the impact of various parameters on the pharmacokinetics and efficacy of in vivo expressed DNA-based anti-HER2 monoclonal antibodies (mAbs), newly engineered and delivered via

Oestradiol valerate pretreatment in GnRH-antagonist cycles: a randomized controlled trial.

Christophe Blockeel et al.

Reproductive biomedicine online, 24(3), 272-280 (2012-02-03)

This randomized controlled trial analyses the ability to control the oocyte retrieval schedule of gonadotrophin-releasing hormone antagonist cycles through the administration of oestradiol valerate during the luteo-follicular transition period prior to the initiation of ovarian stimulation. Eighty-six women undergoing ovarian

Predictive markers for mammoplasty and a comparison of side effect profiles in transwomen taking various hormonal regimens.

L J Seal et al.

The Journal of clinical endocrinology and metabolism, 97(12), 4422-4428 (2012-10-12)

Breast development in transwomen is an important issue, affecting general psychological functioning. Current hormonal therapies are imperfect, with 60% of patients requesting mammoplasty. Interventions included the following: 1) comparing the effects on transwomen's requests for mammoplasty of estrogen valerate, ethinylestradiol