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A9847

Sigma-Aldrich

Angiopoietin-2 human

>97% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

Synonym(s):

Ang-2

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About This Item

MDL number:
MFCD01867019
UNSPSC Code:
12352202
NACRES:
NA.32

biological source

human

Quality Level

200

recombinant

expressed in NSO cells

Assay

>97% (SDS-PAGE)

form

lyophilized powder

mol wt

66 kDa by SDS-PAGE (reducing and non-reducing conditions)
 66 kDa by SDS-PAGE

packaging

pkg of 25 μg

storage condition

avoid repeated freeze/thaw cycles (Do not store in a frost-free freezer.)

impurities

endotoxin, tested

UniProt accession no.

O15123

storage temp.

−20°C

Gene Information

human ... ANGPT2(285)

Biochem/physiol Actions

This ligand is a naturally occurring inhibitor of angiopoietin-1 and Tie-2 both in vivo and in vitro, and has important roles in embryogenic angiogenesis and maintaining the integrity of adult vasculature.

Physical form

Lyophilized from a 0.2 μm filtered solution in 20 mM MOPS, 500 mM NaCl, 0.1% PEG-8000, 0.2% CHAPS, pH 7.0 containing 50 μg bovine serum albumin per 1 μg of cytokine.

Analysis Note

The biological activity is measured a competitive binding assay.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Yang, et al.
Cell Death & Disease, 14, 344-344 (2023)
B Witzenbichler et al.
The Journal of biological chemistry, 273(29), 18514-18521 (1998-07-11)
Angiopoietin-1 and its putative natural antagonist, angiopoietin-2, were recently isolated, and the critical role of angiopoietin-1 in embryogenic angiogenesis was demonstrated by targeted gene disruption. Specific biological effects of angiopoietin-1, however, have yet to be defined. In this study we
Hsiu-Mei Chen et al.
Oncotarget, 6(17), 14940-14952 (2015-04-25)
Foretinib, a multiple kinase inhibitor undergoing clinical trials, could suppress the activity of hepatocyte growth factor (HGF) receptor c-MET and vascular endothelial growth factor receptor-2 (VEGFR-2). In addition, Foretinib may inhibit two critical lymphangiogenic signaling receptors VEGFR-3 and TIE-2. However

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