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Robenidine hydrochloride

VETRANAL®, analytical standard

Synonym(s):

1,3-Bis[(4-chlorobenzylidene)amino]guanidine monohydrochloride

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About This Item

Empirical Formula (Hill Notation):
C15H13Cl2N5 · HCl
CAS Number:
25875-50-7
Molecular Weight:
370.66
EC Number:
247-307-8
MDL number:
MFCD01724404
UNSPSC Code:
41116107
PubChem Substance ID:
329754719
NACRES:
NA.24

grade

analytical standard

Quality Level

100

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

SMILES string

Cl[H].Clc1ccc(cc1)\C=N\NC(=N)N\N=C\c2ccc(Cl)cc2

InChI

1S/C15H13Cl2N5.ClH/c16-13-5-1-11(2-6-13)9-19-21-15(18)22-20-10-12-3-7-14(17)8-4-12;/h1-10H,(H3,18,21,22);1H/b19-9+,20-10+;

InChI key

LTWIBTYLSRDGHP-HCURTGQUSA-N

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General description

Robenidine hydrochloride is a coccidiostat and antibiotic, used in controlling coccidiosis.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Robenidine hydrochloride has been used as a reference standard in the determination of robenidine hydrochloride in eggs using online solid-phase extraction with liquid chromatography coupled with tandem mass spectrometry (SPE-LC-MS/MS).

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

related product

Product No.
Description
Pricing

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCJ1061
BCBW6546
BCBS8398V
SZBD099XV
SZBA074XV

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Binh Nguyen et al.
Journal of the American Chemical Society, 124(46), 13680-13681 (2002-11-15)
A combination of biophysical techniques has been used to characterize the interaction of an antitrypanosomal agent, CGP 40215A, with DNA. The results from a broad array of methods (DNase I footprinting, surface plasmon resonance, X-ray crystallography, and molecular dynamics) indicate
Binh Nguyen et al.
Biophysical journal, 86(2), 1028-1041 (2004-01-30)
Many dicationic amidine compounds bind in the DNA minor groove and have excellent biological activity against a range of infectious diseases. Para-substituted aromatic diamidines such as furamidine, which is currently being tested against trypanosomiasis in humans, and berenil, which is
O Heby et al.
Amino acids, 33(2), 359-366 (2007-07-05)
Trypanosomatids depend on spermidine for growth and survival. Consequently, enzymes involved in spermidine synthesis and utilization, i.e. arginase, ornithine decarboxylase (ODC), S-adenosylmethionine decarboxylase (AdoMetDC), spermidine synthase, trypanothione synthetase (TryS), and trypanothione reductase (TryR), are promising targets for drug development. The
Martin Hansen et al.
Chemosphere, 86(2), 212-215 (2011-11-04)
Two anticoccidial agents, salinomycin and robenidine, heavily used in the worldwide veterinary meat production, were investigated for their potential biotic degradation by cultured soil bacteria. The degradation-study was performed in lab-scale bio-reactors under aerobic and anaerobic conditions incubated for 200
B Stephen et al.
Veterinary parasitology, 69(1-2), 19-29 (1997-04-01)
Ten Eimeria field isolates from North Germany were studied in battery tests for sensitivity to selected anticoccidials. A high percentage of the Eimeria field isolates (9 out of 10) showed resistance to anticoccidials, mostly multiple resistance. Partial or complete resistance
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