L091000

N,N-Dimethylformamide

• Synonym(s): DMF, NSC 5356
• Linear Formula: HCON(CH₃)₂
• CAS Number: 68-12-2
• Molecular Weight: 73.09
• Beilstein: 605365
• EC Number: 200-679-5
• MDL number: MFCD00003284
• UNSPSC Code: 12352111
• PubChem Substance ID: 329817380
• NACRES: NA.51

Properties

• vapor density: 2.5 (vs air)
• vapor pressure: 2.7 mmHg ( 20 °C)
• type: for DNA synthesis
• product line: Proligo Reagents
• form: liquid
• autoignition temp.: 833 °F
• expl. lim.: 15.2 %
• storage condition: dry at room temperature
• impurities: ≤200 ppm water content (Karl Fischer); ≤9 ppm Amine content
• color: clear
• refractive index: n20/D 1.430 (lit.)
• pH: 6.7
• bp: 153 °C (lit.)
• mp: −61 °C (lit.)
• density: 0.944 g/mL (lit.)
• SMILES string: [H]C(=O)N(C)C
• InChI: 1S/C3H7NO/c1-4(2)3-5/h3H,1-2H3
• InChI key: ZMXDDKWLCZADIW-UHFFFAOYSA-N

Description

General description

N,N-Dimethylformamide (DMF) is an amide that works as a multipurpose reagent that is an effective polar solvent for various compounds and a ligand for metallic compounds. It also acts as a key intermediate as an electrophilic or nucleophilic agent for mediating reactions as it delivers its own H, C, N, and O atoms in compound synthesis.

Application

DMF is a widely used polar solvent in which organic, organometallic, and bioorganic transformations are carried out. It is also a solvent for many hydrophobic organic compounds and acts as a source of building blocks in various organic synthesis reactions.

Solvent for many hydrophobic organic compounds.

Safety Information

• Pictograms: GHS02,GHS08,GHS07
• Signal Word: Danger
• Hazard Statements: H226,H312 + H332,H319,H360D
• Precautionary Statements: P210 - P280 - P303 + P361 + P353 - P304 + P340 + P312 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Eye Irrit. 2 - Flam. Liq. 3 - Repr. 1B
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 2
• Flash Point(F): 135.5 °F - closed cup
• Flash Point(C): 57.5 °C - closed cup