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Key Documents

760919

Sigma-Aldrich

Poly(ethylene glycol), 8 acetylene dendron, generation 2

average Mn 6,900

Synonym(s):

Polyethylene glycol

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About This Item

UNSPSC Code:
12162002
NACRES:
NA.23

description

Esterified with 8 acetylene groups

Quality Level

form

solid

mol wt

PEG average Mn 6,000
average Mn 6,900

feature

generation 2

no. Surface Groups

8

transition temp

Tm 47-52 °C

functional group

alkyne

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General description

Dendrimers and dendrons are symmetrically branched polymer structures that possess a well-defined spatial distribution of functional groups. Dendrimers are chemically modified by attaching Poly ethylene glycol (PEG) molecule to increase its solubility and prolong circulation half-life. Clickable groups”, such as primary acetylenes, are introduced to the mono dispersed dendritic structures, using “click” chemistry.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Biocompatible Dendritic Building Blocks for Advanced Biomedical Reasearch
Michael Malkoch and Andreas M Nystrom
Material Matters, 7(3), 47-49 null
Degradable Poly (ethylene glycol) hydrogels for 2 D and 3D cell culture
Andrea M Kasko
Material Matters, 6 (3), 67-75 null
Huiyuan Li et al.
Molecules (Basel, Switzerland), 18(8), 9797-9817 (2013-08-21)
Click chemistry is an efficient and chemoselective synthetic method for coupling molecular fragments under mild reaction conditions. Since the advent in 2001 of methods to improve stereochemical conservation, the click chemistry approach has been broadly used to construct diverse chemotypes

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