36295
2,3-Dichloro-1-propanol
≥97.0% (GC)
Synonym(s):
Glycerol-α,β-dichlorohydrin
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About This Item
Linear Formula:
ClCH2CHClCH2OH
CAS Number:
Molecular Weight:
128.99
Beilstein:
1732060
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
Recommended Products
Assay
≥97.0% (GC)
density
1.360 g/mL at 20 °C (lit.)
SMILES string
OCC(Cl)CCl
InChI
1S/C3H6Cl2O/c4-1-3(5)2-6/h3,6H,1-2H2
InChI key
ZXCYIJGIGSDJQQ-UHFFFAOYSA-N
General description
2,3-Dichloro-1-propanol belongs to the group of chloropropanols. Inhibitory effects of 2,3-dichloro-1-propanol on T cell both in vivo and in vitro is reported. Improved enantioselective resolution of (R,S)-2,3-dichloro-1-propanol to (S)-2, 3-dichloro-1-propanol by whole cells of a recombinant Escherichia coli in n-heptane-aqueous biphasic system is reported.
Application
2,3-Dichloro-1-propanol may be employed as carbon and energy supplement for the growth of Pseudomonas putida strain (MC4).
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 2 Dermal - Acute Tox. 3 Oral - Eye Irrit. 2
Storage Class Code
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
Flash Point(F)
199.4 °F
Flash Point(C)
93 °C
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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Yoshiki Kuroda et al.
Journal of UOEH, 24(3), 271-280 (2002-09-19)
A rare outbreak of acute hepatic damage in workers exposed to dichloropropanols was reported in 1992. As there are no detailed reports of dichloropropanols (DCPs) toxicity and its mechanism, we reviewed the toxicity of dichloropropanols using our results. 1) A
Shu-Ping Zou et al.
Journal of biotechnology, 188, 42-47 (2014-08-26)
The enantioselective resolution of (R,S)-2,3-dichloro-1-propanol ((R,S)-DCP) to (S)-DCP by whole cells of a recombinant Escherichia coli expressing halohydrin dehalogenase (HHDH) activity was limited by product inhibition. To solve this problem to improve the productivity of (S)-DCP, an n-heptane-aqueous biphasic system
Ijaz Gul et al.
Biotechnology and applied biochemistry, 67(4), 685-692 (2020-02-18)
Epoxides are widely used chemicals, the determination of which is of paramount importance. Herein, we present an enzyme-based approach for noninstrumental detection of epoxides in standard solution and environmental samples. Halohydrin dehalogenase (HheC) as a biological recognition element and epichlorohydrin
K Imazu et al.
Journal of UOEH, 14(1), 73-76 (1992-03-01)
We investigated the toxicity of dichloropropanols (DCPs) in hematological findings and serum chemistry. The solutions of two isomers of DCPs, 1,3-dichloro-2-propanol (DC2P) and 2,3-dichloro-1-propanol (DC1P) were dissolved in saline at the concentration of 100 mg/ml, and 0.1 ml of each
Jing Lu et al.
International immunopharmacology, 17(2), 321-328 (2013-07-16)
2,3-Dichloro-1-propanol (2,3-DCP) is a member of a group of chemicals known as chloropropanols. Currently, immunotoxicity of 2,3-DCP has not been reported. In the present study, we studied its inhibitory effects on T cell both in vivo and in vitro. The
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