40334

N-Nitrosodiethylamine (NDEA) solution

certified reference material, 5000 μg/mL in methanol

• Synonym(s): Diethylnitrosamine
• CAS Number: 55-18-5
• UNSPSC Code: 41116105
• MDL number: MFCD00013890
• NACRES: NA.24

Properties

• Quality Segment: 300
• product line: TraceCERT^®
• grade: certified reference material, TraceCERT^®
• CofA: current certificate can be downloaded
• packaging: ampule of 1 mL
• manufacturer/tradename: Manufactured by: Sigma-Aldrich Production GmbH, Switzerland
• concentration: 5000 μg/mL in methanol
• technique(s): HPLC: suitable, chromatography: suitable, gas chromatography (GC): suitable
• application(s): cleaning products; cosmetics; environmental; food and beverages; personal care; pharmaceutical
• format: single component solution
• storage temp.: 2-8°C
• SMILES string: N(N=O)(CC)CC
• InChI: 1S/C4H10N2O/c1-3-6(4-2)5-7/h3-4H2,1-2H3
• InChI key: WBNQDOYYEUMPFS-UHFFFAOYSA-N

Description

General description

Nitrosamines are chemical compounds that can form during drug manufacturing and may pose health risks, including carcinogenicity.
N-Nitrosodiethylamine (NDEA) solution is commonly employed as a certified reference compound in analytical chemistry. It is utilized in chromatographic and spectrometric techniques for the detection and quantification of nitrosamines in chemical, pharmaceutical, and environmental matrices.

Application

N-Nitrosodiethylamine (NDEA) solution may be used as an analytical reference standard for the quantification of nitrosamine impurities and precursors in drug products using liquid gas chromatography-mass spectrometry (GC-MS).

Analysis Note

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with  ISO 17034  and  ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Legal Information

TraceCERT is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS02,GHS06,GHS08
• Signal Word: Danger
• Hazard Codes: H225,H301 + H311 + H331,H350,H370
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Carc. 1B - Flam. Liq. 2 - STOT SE 1
• Target Organs: Eyes,Central nervous system
• Storage Class: 3 - Flammable liquids
• Flash Point (°F): 49.5 °F - closed cup
• Flash Point (°C): 9.7 °C - closed cup
• Precautionary Statements: P210 - P280 - P301 + P310 + P330 - P303 + P361 + P353 - P304 + P340 + P311 - P308 + P311