Z0878

Zaprinast

cGMP-specific phosphodiesterases V and VI inhibitor, solid

• Synonym(s): 1,4-Dihydro-5-(2-propoxyphenyl)-7H-1,2,3-triazolo(4,5-d)pyrimidin-7-one
• Empirical Formula (Hill Notation): C₁₃H₁₃N₅O₂
• CAS Number: 37762-06-4
• Molecular Weight: 271.27
• NACRES: NA.77
• PubChem Substance ID: 24278072
• UNSPSC Code: 12352202
• EC Number: 253-655-1
• MDL number: MFCD00214073
• Form: solid

Properties

• Product Name: Zaprinast, solid
• form: solid
• Quality Segment: 200
• color: white
• solubility: 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.11 mg/mL, DMSO: 10 mg/mL, H₂O: insoluble
• SMILES string: CCCOc1ccccc1C2=NC(=O)c3nn[nH]c3N2
• InChI: 1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19)
• InChI key: REZGGXNDEMKIQB-UHFFFAOYSA-N
• Gene Information: human ... PDE2A(5138), PDE4A(5141), PDE4B(5142), PDE4D(5144)

Description

Application

Zaprinast has been used to determine its inhibitory effect on the meiosis of oocytes by germinal vesicle breakdown (GVBD) assay and to test the inhibitory effect of it on the retinal cells by immunohistochemistry.

Biochem/physiol Actions

Selective inhibitor of cGMP-specific phosphodiesterases V and VI (PDE5/6) and an agonist at the G protein-coupled receptor 35 (GPR35).

Zaprinast insubstantially inhibits phosphodiesterase 10 and 11 (PDE10 and PDE11). It also exhibits vasodilating effects.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves