UC167

Oxidized Nifedipine

powder, ~95% (HPLC)

• Synonym(s): 2,6-Dimethyl-4-(2´-nitrophenyl)-3,5-pyridinecarboxylic acid dimethyl ester
• Empirical Formula (Hill Notation): C₁₇H₁₆N₂O₆
• CAS Number: 67035-22-7
• Molecular Weight: 344.32
• NACRES: NA.77
• PubChem Substance ID: 329827652
• UNSPSC Code: 12161501
• MDL number: MFCD00153847
• Assay: ~95% (HPLC)
• Form: powder

Properties

• assay: ~95% (HPLC)
• Quality Segment: 200
• form: powder
• color: yellow
• mp: 100-105 °C
• storage temp.: 2-8°C
• SMILES string: COC(=O)c1c(C)nc(C)c(C(=O)OC)c1-c2ccccc2[N+]([O-])=O
• InChI: 1S/C17H16N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8H,1-4H3
• InChI key: UMQHJQGNGLQJPF-UHFFFAOYSA-N

Description

Application

Oxidized nifedipine has been used for apoptotic signaling studies in dopaminergic neurons.

Oxidized Nifedipine may be used:

• to study enzyme kinetics using UV high-performance liquid chromatography (UV-HPLC)
• as a standard in calibration curve preparation in high-performance liquid chromatography (HPLC) for the quantification of cytochrome P450 3A4 (CYP3A4)-mediated nifedipine oxidation in human microsomes
• in nifedipine metabolism activity assay of Hep G2 cells transfected with hepatocyte nuclear factor-1α(HNF1α)

Biochem/physiol Actions

CYP3A4 nifedipine metabolite. Nifedipine (parent compound) is an antianginal and antihypertensive agent.

Nifedipine is a dihydropyridine derivative and a calcium channel blocker. It is used in treating hypertension and angina pectoris. Oxidized Nifedipine is an oxidation product of nifedipine generated either by exposure to UV or day light. The enzyme cytochrome P450 3A (CYP3A4) metabolizes nifedipine.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Safety Information

• pictograms: GHS05
• signalword: Danger
• hcodes: H318
• pcodes: P280 - P305 + P351 + P338
• Hazard Classifications: Eye Dam. 1
• Storage Class: 11 - Combustible Solids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves