T3077

TRO 19622

≥98% (HPLC), solid

• Synonym(s): Cholest-4-en-3-one, oxime, NSC 21311, Olesoxime
• Empirical Formula (Hill Notation): C₂₇H₄₅NO
• CAS Number: 22033-87-0
• Molecular Weight: 399.65
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: solid
• Quality level: 100

Properties

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: solid
• color: white
• solubility: DMSO: >10 mg/mL
• storage temp.: −20°C
• InChI: 1S/C27H45NO/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28-29)13-15-26(20,4)25(22)14-16-27(23,24)5/h17-19,22-25,29H,6-16H2,1-5H3/b28-21+
• InChI key: QNTASHOAVRSLMD-SGWCAAJKSA-N

Description

Application

TRO 19622 has been used as a mitochondrial permeability transition pore inhibitor in mouse neurons². TRO 19622 is also known to stimulate myelin repair in rat models of demyelination³.

Biochem/physiol Actions

TRO 19622 can decrease axonal degradation and enhance the rescue of motor nerve conduction in peripheral neuropathy. Furthermore, TRO 19622 can reverse neuropathic pain and tactile allodynia in rat models of diabetes and chemotherapy-induced neuropathic pain⁴.

TRO19622 ia a neuroprotective agent for motor neurons; candidate therapeutic for amyotrophic lateral sclerosis (ALS).

Preparation Note

TRO 19622 is soluble in DMSO at a concentration that is greater than 10 mg/ml.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable