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Annexin V human

Name: Annexin V human
Brand: SIGMA

recombinant, expressed in E. coli, GST tagged, ≥95% (SDS-PAGE)

Synonym(s):

Annexin A5, Calphobindin I, EC 2.7.1.23, Endonexin II, Placental anticoagulantprotein I

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About This Item

NACRES:

NA.32

UNSPSC Code:

12352200

Form:

lyophilized

Assay:

≥95% (SDS-PAGE)

Biological source:

human

Recombinant:

expressed in E. coli

Mol wt:

~52 kDa

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Properties

biological source

human

recombinant

expressed in E. coli

tag

GST tagged

assay

≥95% (SDS-PAGE)

form

lyophilized

mol wt

~52 kDa

packaging

pkg of 100 μg

storage condition

avoid repeated freeze/thaw cycles

technique(s)

activity assay: suitable

color

white

UniProt accession no.

P08758

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... ANXA5(308)

Description

General description

Annexin V is a member of the annexin family of calcium and membrane-binding proteins that have anticoagulatory and anti-inflammatory properties. The encoded protein is 320 amino acid long and is folded into four domains, each having five α-helices, forming a superhelical globular structure. The ANX5 gene is mapped to human chromosome 4q26-q28 and spans a length of 28kb containing 13 exons and 12 introns.

Application

Annexin V has been used to examine phosphorylation activity of ChaK1 (channel-kinase 1).

Biochem/physiol Actions

Annexins are a family of water-soluble proteins that bind to membranes and phospholipids in a calcium-dependent manner. They participate in several cellular functions, such as membrane fusion and cytoskeletal interaction. Annexin V is a potent anticoagulant and serves as a voltage-gated calcium channel when bound to membrane in vitro. It is found to inhibit phospholipase A2 and protein kinase C.

Physical form

Lyophilized from PBS, pH 7.4.

Preparation Note

Reconstitute with 100 μL deionized water.

Other Notes

Recombinant human annexin V fused to a GST-tag.

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This Item	A9460	A8604	A9210
Sigma-Aldrich SRP8026 Annexin V human	Sigma-Aldrich A9460 Annexin V from human placenta	Sigma-Aldrich A8604 Anti-Annexin V antibody, Mouse monoclonal	Sigma-Aldrich A9210 Annexin V FITC Conjugate from human placenta
description recombinant, expressed in E. coli, GST tagged, ≥95% (SDS-PAGE)	description ≥90% (SDS-PAGE), buffered aqueous solution	description clone AN5, purified from hybridoma cell culture	description -
biological source human	biological source human placenta	biological source mouse	biological source -
technique(s) activity assay: suitable	technique(s) cell based assay: suitable	technique(s) immunocytochemistry: suitable, microarray: suitable, western blot: 0.5-1 μg/mL using HeLa total cell extract, indirect ELISA: suitable	technique(s) -
recombinant expressed in E. coli	recombinant -	recombinant -	recombinant -
assay ≥95% (SDS-PAGE)	assay ≥90% (SDS-PAGE)	assay -	assay -
form lyophilized	form buffered aqueous solution	form buffered aqueous solution	form buffered aqueous solution
mol wt ~52 kDa	mol wt 33 kDa (four subunits)	mol wt antigen ~35 kDa	mol wt -

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Storage Class

10 - Combustible liquids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

P26921708

29762105

P1708906

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