SML3754

SRT2104

≥98% (HPLC)

• Synonym(s): 4-Methyl-N-(2-(3-(morpholinomethyl)imidazo[2,1-b]thiazol-6-yl)phenyl)-2-(pyridin-3-yl)thiazole-5-carboxamide, 4-Methyl-N-(2-{3-[(morpholin-4-yl)methyl]imidazo[2,1-b][1,3]thiazol-6-yl}phenyl)-2-(pyridin-3-yl)-1,3-thiazole-5-carboxamide, GSK 2245840B, GSK-2245840B, GSK2245840B, SRT 2104, SRT-2104
• Empirical Formula (Hill Notation): C₂₆H₂₄N₆O₂S₂
• CAS Number: 1093403-33-8
• Molecular Weight: 516.64
• UNSPSC Code: 12352200
• NACRES: NA.21
• MDL number: MFCD22572733
• Assay: ≥98% (HPLC)
• Form: powder
• Quality level: 100

Properties

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear (Warmed)
• storage temp.: -10 to -25°C
• SMILES string: [s]1c(nc(c1C(=O)Nc3c(cccc3)c4nc5[s]cc([n]5c4)CN6CCOCC6)C)c2cnccc2
• InChI key: LAMQVIQMVKWXOC-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Orally active sirtuin 1 (Sirt1) activator in vitro and in vivo.

SRT2104 is an orally active, potent and highly selective activator of the NAD+-dependent deacetylase sirtuin Sirt1 (EC1.5 = 450 nM) with in vivo efficacy in various animal models, including age-related bone/muscle loss (100 mg/kg/d via chow to mice), HD (0.5% in chow to mice), TNF-induced optic nerve degeneration (2-200 pmol via intravitreal injection to rats).

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable