In powdered form, this product may be stored at room temperature. The stability of this material is solution has not been evaluated. However, external sources indicate that stock solutions prepared in DMSO may be stored at -20 C for up to 1 month and at -80C for 6 months. This item is not assigned an expiration or retest date and is robust in nature, being extremely stable in the original, unopened container. Products that are not assigned an expiration or retest date are covered by a warranty period of 1 year from the date of product shipment. Please see the link below to review the full Product Dating Information statement:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/190/408/product-dating-information-ms.pdf?.
SML3651
Deschloroclozapine
≥98% (HPLC), muscarinic-based DREADDs (Designer Receptors Exclusively Activated by Designer Drugs) ligand, powder
Synonym(s):
11-(4-Methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine, DCZ
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About This Item
Empirical Formula (Hill Notation):
C18H20N4
CAS Number:
Molecular Weight:
292.38
UNSPSC Code:
12352200
NACRES:
NA.21
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Pricing and availability is not currently available.
Product Name
Deschloroclozapine, ≥98% (HPLC)
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
Deschloroclozapine (DCZ) is a potent and selective DREADDs (Designer Receptors Exclusively Activated by Designer Drugs) agonist (hM3Dq/hM4Di Ki = 6.3/4.2 nM vs hM3/hM4 Ki = 230/210 nM; hM3Dq/hM4Di EC50 = 130/81 nM by celluar BRET assays) with much greater potency than CNO and C21. DCZ selectively stimulates DREADDs, but not non-DREADDs, cells (Ca2+ EC50 = 2.3 nM/hM3Dq, cAMP IC50 = 0.0048 nM/hM4Di, β-arrestin recruitment EC50 = 0.63 nM/hM3Dq & 0.048 nM/hM4Di). DCZ enhances neuronal activity in hM3Dq mice (1 μg/kg i.p.) & monkeys (1-3 μg/kg i.v.) and induces spatial working memory deficits in hM4Di monkeys (100 μg/kg i.m.) in vivo.
Potent muscarinic-based DREADDs (Designer Receptors Exclusively Activated by Designer Drugs) ligand with in vivo CNS potency.
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This Item | |||
|---|---|---|---|
| description ≥98% (HPLC) | description - | description ≥98% (HPLC) | description ≥98% (HPLC), Water soluble Clozapine N-oxide |
| form powder | form powder | form powder | form powder |
| assay ≥98% (HPLC) | assay - | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 100 | Quality Level 200 | Quality Level 100 | Quality Level - |
| storage temp. 2-8°C | storage temp. - | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility DMSO: 2 mg/mL, clear | solubility - | solubility DMSO: 30 mg/mL, clear | solubility DMSO: 40 mg/mL, water: 40 mg/mL |
| color white to beige | color - | color white to beige | color - |
Signal Word
Danger
Hazard Codes
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Oral
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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