SML3634

TRULI

≥98% (HPLC), YAP signaling activator, powder

• Synonym(s): N-(3-Benzylthiazol-2(3H)-ylidene)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide
• Empirical Formula (Hill Notation): C₁₈H₁₄N₄OS
• CAS Number: 1424635-83-5
• Molecular Weight: 334.39
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Product Name: TRULI, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: O=C(C1=CNC2=C1C=CC=N2)N=C3SC=CN3CC4=CC=CC=C4
• InChI: 1S/C18H14N4OS/c23-17(15-11-20-16-14(15)7-4-8-19-16)21-18-22(9-10-24-18)12-13-5-2-1-3-6-13/h1-11H,12H2,(H,19,20)
• InChI key: VTXBMVZVPUSAJF-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Cell penetrant, potent and non-toxic activator of Yap signaling; inhibitor of Lats kinases

TRULI is a call penetrant, potent and non-toxic activator of Yap signaling. TRULI is an ATP-competitive inhibitor of Lats kinases (the core enzymes in Hippo signaling) that induces robust Yap nuclear translocation and prevents Yap phosphorylation. TRULI induces proliferation of supporting cells in the murine inner ear, murine cardiomyocytes, and human Müller glia in retinal organoids.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable