SML3519

Exatecan

≥98% (HPLC), topoisomerase-I inhibitor, powder

• Synonym(s): (1S,9S)-9-Ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-2,3,9,10,13,15-hexahydro-1H,12H-benzo[de]pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-1-amine, DX 8951
• Empirical Formula (Hill Notation): C₂₄H₂₂FN₃O₄
• CAS Number: 171335-80-1
• Molecular Weight: 435.45
• NACRES: NA.77
• UNSPSC Code: 12352200
• MDL number: MFCD00926120
• Assay: ≥98% (HPLC)
• Form: powder
• Quality level: 100

Properties

• Product Name: Exatecan, ≥98% (HPLC)
• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear (Warmed)
• storage temp.: -10 to -25°C
• SMILES string: O=C1N2C(C3=NC4=CC(F)=C(C(CC[C@@H]5N)=C4C5=C3C2)C)=CC6=C1COC([C@@]6(CC)O)=O
• InChI: 1S/C24H22FN3O4/c1-3-24(31)14-6-18-21-12(8-28(18)22(29)13(14)9-32-23(24)30)19-16(26)5-4-11-10(2)15(25)7-17(27-21)20(11)19/h6-7,16,31H,3-5,8-9,26H2,1-2H3/t16-,24-/m0/s1
• InChI key: ZVYVPGLRVWUPMP-FYSMJZIKSA-N

Description

Biochem/physiol Actions

Camptothecin analog that exhibits a stronger topoisomerase-I inhibitory and antitumor activities and is highly effective against P-gp mediated MDR cells

Exatecan is a camptothecin (CPT) analog that exhibits a stronger topoisomerase-I inhibitory and antitumor activities and is highly effective against P-glycoprotein (P-gp) mediated multi-drug resistant cells. Several of the exatecan derivative based antibody-drug and peptide-drug conjugate payloads display high therapeutic indices universally across solid tumors.

Safety Information

• pictograms: GHS06,GHS08
• signalword: Danger
• hcodes: H300,H340,H360F
• pcodes: P202 - P264 - P280 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 2 Oral - Muta. 1B - Repr. 1B
• Storage Class: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable