SML3312

SRI-41315

≥95% (HPLC), readthrough agent, powder

• Synonym(s): 2-Cyclobutyl-10-methyl-3-phenylpyrimido[4,5-b]quinoline-4,5(3H,10H)-dione
• Empirical Formula (Hill Notation): C₂₂H₁₉N₃O₂
• CAS Number: 1613509-49-1
• Molecular Weight: 357.41
• UNSPSC Code: 51111800
• NACRES: NA.32
• Assay: ≥95% (HPLC)
• Form: powder
• Quality level: 100
• Storage condition: desiccated

Properties

• Product Name: SRI-41315, ≥95% (HPLC)
• Quality Level: 100
• assay: ≥95% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear (Warmed)
• storage temp.: -10 to -25°C
• SMILES string: O=C1N(C2=CC=CC=C2)C(C3CCC3)=NC4=C1C(C5=CC=CC=C5N4C)=O

Description

Biochem/physiol Actions

Cell penetrant and potent readthrough agents that suppress translation termination at premature termination codon

SRI-41315 is a cell penetrant and potent readthrough agents that suppress translation termination at premature termination codon and allows translation elongation to continue in the correct reading frame and generate a full-length protein. SRI-41315 induces the translational pause that occurs at premature termination codons by depleting eRF1 protein levels through a proteasome-mediated degradation pathway. SRI-41315 restores CFTR expression and function in in immortalized and primary human bronchial epithelial cells.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable