SML3162

A-1155463

≥98% (HPLC)

• Synonym(s): 2-[8-[(2-Benzothiazolylamino)carbonyl]-3,4-dihydro-2(1H)-isoquinolinyl]-5-[3-[4-[3-(dimethylamino)-1-propyn-1-yl]-2-fluorophenoxy]propyl]-4-thiazolecarboxylic acid, A 1155463
• Empirical Formula (Hill Notation): C₃₅H₃₂FN₅O₄S₂
• CAS Number: 1235034-55-5
• Molecular Weight: 669.79
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD29924714
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: −20°C
• SMILES string: O=C(C1=C(CN(C2=NC(C(O)=O)=C(CCCOC3=CC=C(C#CCN(C)C)C=C3F)S2)CC4)C4=CC=C1)NC5=NC6=C(S5)C=CC=C6
• InChI: 1S/C35H32FN5O4S2/c1-40(2)17-6-8-22-14-15-28(26(36)20-22)45-19-7-13-30-31(33(43)44)38-35(47-30)41-18-16-23-9-5-10-24(25(23)21-41)32(42)39-34-37-27-11-3-4-12-29(27)46-34/h3-5,9-12,14-15,20H,7,13,16-19,21H2,1-2H3,(H,43,44)(H,37,39,42)
• InChI key: SOYCFODXNRVBTI-UHFFFAOYSA-N

Description

Biochem/physiol Actions

highly potent and selective BCL-XL inhibitor

A-1155643 is a highly potent and highly selective BCLXL inhibitor that inhibits H146 small cell lung cancer xenograft tumor growth in mice.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable