SML2919

Abarelix acetate

• Synonym(s): N-Ac-D-Nal-4-Cl-D-Phe-D-Pal-Ser-N-Me-Tyr-D-Asn-Leu-Lys(iPr)-Pro-D-Ala-NH2, acetate salt, N-Ac-DNal-DCpa-DPal-Ser-Nα-Me-Tyr-DAsn-Leu-ILys-Pro-DAla-NH2, acetate salt, N-Acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-N-methyl-L-tyrosyl-D-asparaginyl-L-leucyl-N6-(1-methylethyl)-L-lysyl-L-prolyl-D-alaninamide, acetate salt, PPI 149 acetate, PPI-149 acetate, PPI149 acetate, R 3827 acetate, R-3827 acetate, R3827 acetate
• Empirical Formula (Hill Notation): C₇₂H₉₅ClN₁₄O₁₄ · xC₂H₄O₂
• CAS Number: 785804-17-3
• Molecular Weight: 1416.06 (free base basis)
• NACRES: NA.77
• UNSPSC Code: 12352200
• Assay: ≥97% (HPLC)
• Form: film or powder

Properties

• assay: ≥97% (HPLC)
• Quality Segment: 100
• form: film or powder
• color: white to beige
• storage temp.: −20°C

Description

Biochem/physiol Actions

Abarelix (PPI-149) is a gonadotropin releasing hormone (GnRH)/luteinizing hormone releasing hormone (LHRH) receptor (GnRHR, LHRHR) antagonist with low histamine release induction propensity (EC₅₀ = 100 μg/mL; rat mast cells). Abarelix exhibits good in vivo efficacy via iv. or sc. in suppressing LH levels in castrated male rats (plasma LH = 12/1.2/0.9/1.2 ng/mL 6 hrs post 0/12.5/50/200 μg/kg in 5% mannitol sc.) and in lowering testosterone among intact male rats (plasma testosterone = 1.64/0.29 ng/mL 6 hrs post 0/3 μg/kg sc.).

Gonadotropin releasing hormone (GnRH)/ luteinizing hormone releasing hormone (LHRH) receptor (GnRHR, LHRHR) antagonist.

Safety Information

• pictograms: GHS08
• signalword: Warning
• hcodes: H361d
• pcodes: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 2
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable