SML2783

VU0409551

≥98% (HPLC)

• Synonym(s): JNJ 46778212, JNJ-46778212, VU 0409551, [6,7-Dihydro-2-(phenoxymethyl)oxazolo[5,4-c]pyridin-5(4H)-yl](4-fluorophenyl)methanone
• Empirical Formula (Hill Notation): C₂₀H₁₇FN₂O₃
• CAS Number: 1363281-27-9
• Molecular Weight: 352.36
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD29047143
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: O=C(N1CCC2=C(C1)OC(COC3=CC=CC=C3)=N2)C4=CC=C(C=C4)F
• InChI key: QUZLMKNNIUSREV-UHFFFAOYSA-N

Description

Biochem/physiol Actions

VU0409551 (JNJ-46778212) is an orally available, potent and selective biased metabotropic glutamate receptor subtype 5 positive allosteric modulator (mGlu5 PAM). VU0409551 (JNJ-46778212) selectively potentiates mGlu5 coupling to Gaq-mediated signaling without modulation of NMDAR currents in hippocampal neurons. VU0409551 exhibits potent antipsychotic-like and cognition enhancing activity in animal models.

orally available, potent and selective biased mGlu5 PAM

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable