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SML2636

Sb4

≥98% (HPLC)

Synonym(s):

2-[[(4-Bromophenyl)methyl]thio]benzoxazole, BMP signaling agonist Sb4

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About This Item

Empirical Formula (Hill Notation):
C14H10BrNOS
CAS Number:
100874-08-6
Molecular Weight:
320.20
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD01603921
Assay:
≥98% (HPLC)
Form:
powder
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assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

BrC1=CC=C(CSC2=NC3=C(C=CC=C3)O2)C=C1

InChI

1S/C14H10BrNOS/c15-11-7-5-10(6-8-11)9-18-14-16-12-3-1-2-4-13(12)17-14/h1-8H,9H2

InChI key

JDVOIBFEFVKUPL-UHFFFAOYSA-N

Biochem/physiol Actions

Cell penetrant, potent bone morphogenetic protein (BMP) signaling agonist that rapidly activate BMP in human renal cells (HEK293)
Sb4 is a cell penetrant, potent bone morphogenetic protein (BMP) signaling agonist that rapidly activate BMP in human renal cells (HEK293). Sb4 activates BMP by stabilization of intracellular p-SMAD-1/5/9. Apparently activation of the BMP pathway by sb4 cannot be reversed by inhibition of Noggin or type I BMP kinase inhibitors

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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