SML2524

Fexinidazole

≥98% (HPLC)

• Synonym(s): 1-methyl-2-[[4-(methylthio)phenoxy]methyl]-5-nitro-1H-imidazole, HOE 239
• Empirical Formula (Hill Notation): C₁₂H₁₃N₃O₃S
• CAS Number: 59729-37-2
• Molecular Weight: 279.31
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00866607
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• assay: ≥98% (HPLC)
• form: powder
• color: light yellow to dark brown
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: −20°C
• SMILES string: CN1C(COC2=CC=C(SC)C=C2)=NC=C1[N+]([O-])=O
• InChI: 1S/C12H13N3O3S/c1-14-11(13-7-12(14)15(16)17)8-18-9-3-5-10(19-2)6-4-9/h3-7H,8H2,1-2H3
• InChI key: MIWWSGDADVMLTG-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Anti Trypanosoma, Leishmania agent.

Fexinidazole is a potent anti-Trypanosoma agent. Trypanosoma species human protozoan pathogens are responsible for sleeping sickness and Chagas disease. In vivo, fexinidazole is oxidized to sulfoxide and sulfone metabolites that are effective in blocking the progression of the parasitic disease visceral leishmaniasis. The mechanism of action appears to be by reductive activation via an NADH-dependent nitroreductase expressed by the parasites.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable