Unfortunately, the solution stability of this product is not determined.
SML2156
Erlotinib hydrochloride
≥98% (HPLC), EGFR kinase inhibitor, powder
Synonym(s):
774 hydrochloride, CP-358, N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride, OSI-744 hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C22H23N3O4 · HCl
CAS Number:
Molecular Weight:
429.90
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated
Pricing and availability is not currently available.
Product Name
Erlotinib hydrochloride, ≥98% (HPLC)
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
DMSO: 2 mg/mL, clear (warmed)
storage temp.
−20°C
SMILES string
Cl.N(c3cc(ccc3)C#C)c1ncnc2c1cc(c(c2)OCCOC)OCCOC
InChI
1S/C22H23N3O4.ClH/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22;/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25);1H
InChI key
GTTBEUCJPZQMDZ-UHFFFAOYSA-N
General description
Erlotinib hydrochloride is an antineoplastic drug. It regulates mechanistic target of rapamycin (mTOR) inhibition, epidermal growth factor receptor down-regulation and epidermal interstitial transformation (EMT) suppression.
Application
Erlotinib hydrochloride has been used to activate mitochondrial fragmentation in a human PANC-1 pancreatic cancer cell line.
Biochem/physiol Actions
EGFR kinase inhibitor; Antineoplastic
Erlotinib hydrochloride is an inhibitor of the receptor tyrosine kinase EGFR (epidermal growth factor receptor). It is used clinically for the treatment of non-small cell lung cancer (NSCLC) and in combination for metastatic pancreatic cancer.
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This Item | |||
|---|---|---|---|
| assay ≥98% (HPLC) | assay - | assay - | assay ≥98% (HPLC) |
| form powder | form - | form solid | form powder |
| storage temp. −20°C | storage temp. - | storage temp. - | storage temp. -10 to -25°C |
| storage condition desiccated | storage condition - | storage condition - | storage condition - |
| solubility DMSO: 2 mg/mL, clear (warmed) | solubility - | solubility - | solubility DMSO: 2 mg/mL, clear |
| color white to beige | color - | color - | color white to beige |
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signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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How long is your erlotinib hydrochloride stable as aliquots dissolved in DMSO or water at -20 degrees? And how long is it stable when added to cell culture medium at 37 degrees at 5% CO2?
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