SML1948

S1QEL1.1

≥98% (HPLC), Mitochondrial complex I inhibitor, powder

• Synonym(s): N1-(3-acetamidophenyl)-N2-(2-(4-methyl-2-(p-tolyl)thiazol-5-yl)ethyl)oxalamide, S1QEL
• Empirical Formula (Hill Notation): C₂₃H₂₄N₄O₃S
• CAS Number: 897613-29-5
• Molecular Weight: 436.53
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Product Name: S1QEL1.1, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• shipped in: wet ice
• storage temp.: −20°C
• SMILES string: CC1=C(CCNC(C(NC2=CC=CC(NC(C)=O)=C2)=O)=O)SC(C3=CC=C(C)C=C3)=N1
• InChI: 1S/C23H24N4O3S/c1-14-7-9-17(10-8-14)23-25-15(2)20(31-23)11-12-24-21(29)22(30)27-19-6-4-5-18(13-19)26-16(3)28/h4-10,13H,11-12H2,1-3H3,(H,24,29)(H,26,28)(H,27,30)
• InChI key: BFNBJUBXXJKBFN-UHFFFAOYSA-N

Description

Application

S1QEL1.1 has been used as a reverse electron transport (RET)-induced mitochondrial (mito) reactive oxygen species (ROS) suppressor:

• to investigate the role of mitochondrial-derived superoxide in triggering ferroptosis
• to study the mechanism involved in the regulation of anti-fungal responses of macrophages against Aspergillus infection
• in combination with mito-antioxidant to study their influence on mitochondria-derived H₂O₂ in cancer cells
• to determine the effect of oxidative stress depletion on myoblast differentiation

Biochem/physiol Actions

S1QEL1.1 is a suppressor of mitochondrial respiratory complex I site IQ electron leak, suppressing superoxide and/or H₂O₂ production without altering oxidative phosphorylation. S1QEL1.1 had an IC50 values of 70 nM against superoxide-H₂O₂ production from site IQ. It decreased caspase activation in a in a cardiomyocyte cell model of ER stress and decreased ischemia-reperfusion injury in the Langendorff-perfused mouse heart model.

Suppressor of mitochondrial respiratory complex I site IQ electron leak, suppressing superoxide and/or H2O2 production without altering oxidative phosphorylation

Suppressors of the site IQ electron leak (S1QEL)1.1 reduces cytokine secretion and fungicidal activity of macrophages infected with swollen A. fumigatus conidia by suppressing reverse electron transport (RET)-induced mitochondrial reactive oxygen species (ROS).

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable