SML1857

LRE1

≥98% (HPLC)

• Synonym(s): 6-Chloro-N4-cyclopropyl-N4-(2-thienylmethyl)-2,4-pyrimidinediamine, RU-0204277
• Empirical Formula (Hill Notation): C₁₂H₁₃ClN₄S
• CAS Number: 1252362-53-0
• Molecular Weight: 280.78
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD23148480
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 10 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: ClC1=CC(N(C2CC2)CC3=CC=CS3)=NC(N)=N1
• InChI key: PDWZXKSZLRVSEH-UHFFFAOYSA-N

Description

Biochem/physiol Actions

LRE1 is a selective allosteric inhibitor of soluble adenylyl cyclase (sAC), a ubiquitously expressed, essential component of cAMP-signaling. In contrast to G-protein-regulated transmembrane adenylyl cyclase, soluble adenylyl cyclase is directly activated by calcium and carbonate, and is dispersed throughout the cell cytoplasm. LRE1 was found to bind to the bicarbonate activator binding site. It inhibited cAMP accumulation in 4-4 cells with an IC50 of 11 μM, similar to that of KH7 and without its cellular toxicity.

Selective allosteric inhibitor of soluble adenylyl cyclase (sAC)

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3