SML1711

TNCA

≥98% (HPLC)

• Synonym(s): (3S)-2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid, L-1,2,3,4-Tetrahydronorharman-3-carboxylic acid, Lycoperodine-1
• Empirical Formula (Hill Notation): C₁₂H₁₂N₂O₂
• CAS Number: 42438-90-4
• Molecular Weight: 216.24
• NACRES: NA.77
• PubChem Substance ID: 329826033
• UNSPSC Code: 12352200
• MDL number: MFCD00272641
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• optical activity: [α]/D -57 to -67°, c = 1 (in MeOH:1N HCl (1:1))
• color: white to beige
• solubility: 1.5 mg/mL, clear (Solvent: 0.1N HCl:DMSO (1:1); warmed)
• storage temp.: −20°C
• SMILES string: O=C(O)[C@H]1NCC2=C(C3=C(N2)C=CC=C3)C1
• InChI: 1S/C12H12N2O2/c15-12(16)10-5-8-7-3-1-2-4-9(7)14-11(8)6-13-10/h1-4,10,13-14H,5-6H2,(H,15,16)/t10-/m0/s1
• InChI key: FSNCEEGOMTYXKY-JTQLQIEISA-N

Description

Biochem/physiol Actions

TNCA is a tryptophan derivative that binds the parathyroid Ca²⁺-sensing receptor (CaSR) extracellular domain (ECD) hinge region between two globular subdomains and acts as a high-affinity CaSR ligand (CaSRL) with co-agonist activity.

TNCA is a tryptophan derivative that binds the parathyroid Ca²⁺-sensing receptor (CaSR) extracellular domain (ECD) hinge region between two globular subdomains and acts as a high-affinity CaSR ligand (CaSRL) with co-agonist activity. TNCA is shown to potentiate both Mg++- and Ca++-evoked cellular calcium response (0.1-0.5 mM), as well as Mg++-evoked cellular ERK1/2 phosphorylation in CaSR-expressing HEK293 cells (0.5 mM). AC-265347 (Cat. No. SML0129), on the other hand, is a calcimimetic that functions as a CaSR agonist.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable