The molecular weight of this compound is 540.70 Daltons. This product is tested for solubility in DMSO. The minimum solubility specification is 25 mg/mL. A review of past lots reveals rates ranging from 40 - 46 mg/ml in DMSO. Please see the link below to access a sample or lot-specific Certificate of Analysis:
https://www.sigmaaldrich.com/product/sigma/sml1175#product-documentation
SML1175
Romidepsin
≥98% (HPLC), powder, histone deacetylase inhibitor
Synonym(s):
Cyclo[(2Z)-2-amino-2-butenoyl-L-valyl-(3S,4E)-3-hydroxy-7-mercapto-4-heptenoyl-D-valyl-D-cysteinyl] cyclic (35)-disulfide, Depsipeptide, FK228, FR901228, L-Valine, N-((3S,4E)-3-hydroxy-7-mercapto-1-oxo-4-heptenyl)-D-valyl-D-cysteinyl-(2Z)-2-amino-2-butenoxyl-, (4-1)-lactone, cyclic (1-2)-disulfide
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About This Item
Empirical Formula (Hill Notation):
C24H36N4O6S2
CAS Number:
Molecular Weight:
540.70
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Pricing and availability is not currently available.
Product Name
Romidepsin, ≥98% (HPLC)
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 25 mg/mL, clear
storage temp.
−20°C
SMILES string
O=C(N/C(C(N[C@@H](C(C)C)C(O[C@@]1([H])CC2=O)=O)=O)=C\C)[C@@H](CSSCC/C=C/1)NC([C@H](N2)C(C)C)=O
InChI
1S/C24H36N4O6S2/c1-6-16-21(30)28-20(14(4)5)24(33)34-15-9-7-8-10-35-36-12-17(22(31)25-16)26-23(32)19(13(2)3)27-18(29)11-15/h6-7,9,13-15,17,19-20H,8,10-12H2,1-5H3,(H,25,31)(H,26,32)(H,27,29)(H,28,30)/b9-7+,16-6-/t15-,17-,19-,20+/m1/s1
InChI key
OHRURASPPZQGQM-GCCNXGTGSA-N
Gene Information
Biochem/physiol Actions
Romidepsin is a very potent natural prodrug inhibitor of HDAC1 and HDAC2 that is converted to active form by glutathione. Romidepsin has IC50 values of 36 nM and 47 nM for HDAC1 and HDAC2, respectively. Romidepsin kills lymphoma cell lines overexpressing Bcl-2 and Bcl-XL, and has been approved for the treatment for cutaneous T-cell lymphoma (CTCL) and peripheral T-cell lymphoma, and a variety of other cancers.
Romidepsin is a very potent natural prodrug inhibitor of HDAC1 and HDAC2; antineoplastic.
Romidepsin promotes apoptosis, while hindering tumor growth in glioma models.
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This Item | |||
|---|---|---|---|
| form powder | form powder | form powder | form powder |
| assay ≥98% (HPLC) | assay ≥98% | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 100 | Quality Level 200 | Quality Level 100 | Quality Level 100 |
| storage temp. −20°C | storage temp. −20°C | storage temp. 2-8°C | storage temp. room temp |
| solubility DMSO: 25 mg/mL, clear | solubility chloroform/methanol (2:1): complete 10 mg/ml, clear to slightly hazy, colorless to light yellow | solubility DMSO: 20 mg/mL, clear | solubility DMSO: 2 mg/mL, clear (warmed) |
| color white to beige | color light yellow | color white to beige | color white to beige |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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How much volume of the solvent do I have to resuspend in it? To get the stock concentration of what? Also what is the molecular weight of the same?
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