SML1169

Pitstop 2

≥98% (HPLC), powder, clathrin-mediated endocytosis inhibitor

• Synonym(s): N-[5-[(4-Bromophenyl)methylene]-4,5-dihydro-4-oxo-2-thiazolyl]-1-naphthalenesulfonamide, Pitstop-2
• Empirical Formula (Hill Notation): C₂₀H₁₃BrN₂O₃S₂
• CAS Number: 1332879-52-3
• Molecular Weight: 473.36
• UNSPSC Code: 12352200
• NACRES: NA.77
• eCl@ss: 32160701
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Product Name: Pitstop 2, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to light brown
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: −20°C

Description

Application

Pitstop 2 has been used as an inhibitor of clathrin-mediated endocytosis.

Biochem/physiol Actions

Pitstop 2 is a selective inhibitor of clathrin-mediated endocytosis that acts via blocking ligand access to the clathrin terminal domain. Pitstop 2 selectively inhibits clathrin-mediated HIV entry and stalls clathrin-coated pit (CCP) dynamics.

Pitstop 2 is a selective inhibitor of clathrin-mediated endocytosis.

Pitstop 2 also has an ability to breakdown the nuclear pore complex (NPC) permeability barrier and decrease importin β binding along with alteration of the NPC ultrastructure. Pitstop 2 is also involved in the inhibition of platelet activation, platelet aggregation and secretion.

Safety Information

• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): No data available
• Flash Point (°C): No data available