SML1045
Thiazovivin
≥98% (HPLC), powder, Rho Kinase inhibitor
Synonym(s):
N-Benzyl-2-(pyrimidin-4-ylamino)thiazole-4-carboxamide
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About This Item
Empirical Formula (Hill Notation):
C15H13N5OS
CAS Number:
Molecular Weight:
311.36
UNSPSC Code:
12352200
NACRES:
NA.77
Product Name
Thiazovivin, ≥98% (HPLC)
Quality Level
assay
≥98% (HPLC)
form
powder
color
, white to beige to brown
solubility
DMSO: 20 mg/mL, clear
storage temp.
−20°C
SMILES string
[s]1c(nc(c1)C(=O)NCc3ccccc3)Nc2ncncc2
InChI
1S/C15H13N5OS/c21-14(17-8-11-4-2-1-3-5-11)12-9-22-15(19-12)20-13-6-7-16-10-18-13/h1-7,9-10H,8H2,(H,17,21)(H,16,18,19,20)
InChI key
DOBKQCZBPPCLEG-UHFFFAOYSA-N
Related Categories
Application
Thiazovivin has been used in the generation of induced pluripotent stem cells (iPSCs) and induced neural stem cells (iNSCs) from human urine cells. It has also been used to study the the effect of pro-fibrotic inhibition on cardiac reprogramming.
Biochem/physiol Actions
Thiazovivin is a Rho Kinase (ROCK) inhibitor that promotes the transformation of fibroblasts into stem cells with a 200-fold efficiency over the classic method when used in combination with ALK5 inhibitor SB-431542 (S4317) and MEK inhibitor PD-0325901 (PZ0162). Thiazovivin stabilizes E-cadherin on the cell surface, necessary for human embryonic stem cell survival in culture. When human embryonic stem cells are cut out from the colony, this key protein is disrupted and then internalized within the cell. Without e-cadherin on the cell surface, cell signaling between the cells and their environment is disrupted and the cells quickly die.
Thiazovivin is a Rho Kinase (ROCK) inhibitor.
Thiazovivin is an inhibitor of Rho associated coiled-coil containing protein kinase (ROCK). In vitro studies prove that thiazovivin is efficient in stimulating better morphology, expression of ionic transporter and protein involved in cell adhesion.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Daniel A Armendariz et al.
eLife, 12 (2023-04-25)
Enhancers orchestrate gene expression programs that drive multicellular development and lineage commitment. Thus, genetic variants at enhancers are thought to contribute to developmental diseases by altering cell fate commitment. However, while many variant-containing enhancers have been identified, studies to endogenously
Generation of Urine Cell-Derived Non-integrative Human iPSCs and iNSCs: A Step-by-Step Optimized Protocol.
Cheng L, et al.
Frontiers in Molecular Neuroscience, 10, 348-348 (2017)
The ROCK inhibitor, thiazovivin, inhibits human corneal endothelial-to-mesenchymal transition/epithelial-to-mesenchymal transition and increases ionic transporter expression.
Wu Q, et al.
International Journal of Molecular Medicine, 40(4), 1009-1018 (2017)
Yonatan R Lewis-Israeli et al.
Journal of visualized experiments : JoVE, (175) (2021-10-05)
The ability to study human cardiac development in health and disease is highly limited by the capacity to model the complexity of the human heart in vitro. Developing more efficient organ-like platforms that can model complex in vivo phenotypes, such
Kelli Johnson et al.
American journal of physiology. Cell physiology, 319(2), C321-C330 (2020-06-20)
Acetylcholine induces robust electrogenic anion secretion in mammalian intestine and it has long been hypothesized that it mediates the epithelial response through the M3 and, to a lesser extent, the M1 muscarinic receptors in the mouse. However, nicotinic receptors have
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML1045-25MG | 04061832451428 |
| SML1045-5MG | 04061832451435 |
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