SML0952

NSC23766 trihydrochloride

≥97% (HPLC), Rac1 inhibitor, powder

• Synonym(s): N6-[2-(4-Diethylamino-1-methyl-butylamino)-6-methyl-pyrimidin-4-yl]-2-methyl-quinoline-4,6-diamine trihydrochloride
• Empirical Formula (Hill Notation): C₂₄H₃₅N₇ · 3HCl
• CAS Number: 1177865-17-6
• Molecular Weight: 530.96
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥97% (HPLC)
• Form: powder
• Storage condition: desiccated

Properties

• Product Name: NSC23766 trihydrochloride, ≥97% (HPLC)
• Quality Segment: 100
• assay: ≥97% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: H₂O: 10 mg/mL, clear
• storage temp.: −20°C
• SMILES string: Cl.Cl.Cl.N(CCCC(Nc1nc(cc(n1)C)Nc2cc3c(nc(cc3N)C)cc2)C)(CC)CC
• InChI: 1S/C24H35N7.3ClH/c1-6-31(7-2)12-8-9-16(3)27-24-28-18(5)14-23(30-24)29-19-10-11-22-20(15-19)21(25)13-17(4)26-22;;;/h10-11,13-16H,6-9,12H2,1-5H3,(H2,25,26)(H2,27,28,29,30);3*1H
• InChI key: CPUHORIUXPQCHW-UHFFFAOYSA-N

Description

Application

NSC23766 trihydrochloride has been used as a ras-related C3 botulinum toxin substrate 1 (RAC1) inhibitor.

Biochem/physiol Actions

NSC23766 is an inhibitor of Rac1, a Rho-family GTPase.

NSC23766 is an inhibitor of Rac1, a Rho-family GTPase. The compound blocks activation by the guanine nucleotide exchange factors Trio and Tiam1, but does not affect interactions with RhoA or Cdc42. NSC23766 blocks ADP-mediated platelet aggregation. Inhibition of Rac1 by NSC23766 restores sensitivity to trastuzumab by restoring down-regulation of ErbB2.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable