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Merck

SML0786

Decursin

From Radix peucedani, ≥97% (HPLC), anticancer agent, powder

Synonym(s):

(+)-Decursin, (7S)-7,8-Dihydro-8,8-dimethyl-2-oxo-2H,6H-benzo[1,2-b:5,4-b′]dipyran-7-yl 3-methyl-2-butenoate, 3-Methyl-2-butenoic acid (7S)-7,8-dihydro-8,8-dimethyl-2-oxo-2H,6H-pyrano[3,2-g]-1-benzopyran-7-yl ester

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About This Item

Empirical Formula (Hill Notation):
C19H20O5
CAS Number:
5928-25-6
Molecular Weight:
328.36
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00272154
Assay:
≥97% (HPLC)
Form:
powder
Quality level:
100

Key Documents

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Product Name

Decursin, ≥97% (HPLC)

biological source

Radix peucedani

Quality Level

100

assay

≥97% (HPLC)

form

powder

optical activity

[α]/D +120 to +160°, c = 0.5 in chloroform-d

color

white to beige

solubility

DMSO: 5 mg/mL, clear

shipped in

wet ice

storage temp.

−20°C

SMILES string

[o]1c2c(cc3c(c2)OC([C@H](C3)OC(=O)C=C(C)C)(C)C)cc[c]1=O

InChI

1S/C19H20O5/c1-11(2)7-18(21)23-16-9-13-8-12-5-6-17(20)22-14(12)10-15(13)24-19(16,3)4/h5-8,10,16H,9H2,1-4H3/t16-/m0/s1

InChI key

CUKSFECWKQBVED-INIZCTEOSA-N

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Biochem/physiol Actions

Decursin is a cumarin isolated from Radix peucedani that exhibits a number of physiological actions including anticancer, antibacterial, antinematodal and antioxidant.
Decursin is a cumarin isolated from Radix peucedani that exhibits a number of physiological actions including anticancer, antibacterial, antinematodal and antioxidant. Decursin is potent anti-angiogenic agent targeting the VEGFR-2 signaling pathway. Decursin exhibits potent neuroprotective activity against glutamate and Ab- induced neurotoxicity. Apparently, decursin stimulates activation of Nerf2. Also, decursin inhibits androgen stimulated AR translocation to the nucleus in LNCaP prostate cancer cells.

Features and Benefits

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000426820
0000426820
0000279566
0000215000
0000214999

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Jung-woo Chae et al.
Journal of ethnopharmacology, 144(2), 248-254 (2012-09-18)
Decursin is used as a traditional Asian medicine to treat various women's diseases. Herb-drug interaction has become a serious problem since herbal medicine is extensively used in the modern world. This study investigates effects of decursin, on the pharmacokinetics of
Sa-Ra Choi et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 49(10), 2517-2523 (2011-06-23)
Decursin is a major biological active component of Angelicagigas Nakai and is known to induce apoptosis of metastatic prostatic cancer cells. However, the apoptotic mechanism of decursin using primary malignant tumor (RC-58T/h/SA#4)-derived human prostate cells is not known. In the
Kyeong-Ok Choi et al.
Journal of medicinal food, 15(10), 863-872 (2012-10-09)
The root of Angelica gigas (Korean angelica) is traditionally used to treat women's ailments that are caused by an impairment of menstrual blood flow and cycle irregularities. This study evaluated the effect particle size of Korean angelica powder on its
Nam Il Park et al.
Molecular biotechnology, 50(2), 114-120 (2011-06-01)
Angelica gigas is a medicinal plant that produces pyranocoumarins, including decursin (D) and decursinol angelate (DA), which have neuroprotective, anticancer, and antiandrogenic effects. In this study, the coumarin biosynthetic pathway was engineered to increase the production of DA. Specifically, a
In Sik Kim et al.
Molecular biology reports, 40(3), 2541-2548 (2013-01-08)
(S)-(+)-decursin is a biological coumarin compound isolated from Angelica gigas Nakai. (S)-(+)-decursin and its analogue have a variety of pharmacological activities. In the present study, the anti-inflammatory effect of a (S)-(+)-decursin derivative, (S)-(+)-3-(3,4-dihydroxy-phenyl)-acrylic acid 2,2-dimethyl-8-oxo-3,4-dihydro-2H,8H-pyrano [3,2-g]-chromen-3-yl-ester (Compound 6, C6), on
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Global Trade Item Number

SKUGTIN
SML0786-1MG04061826293669
SML0786-5MG04061832724089

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