SML0507

NPC26

≥98% (HPLC)

• Synonym(s): 4,5,6,7-Tetrahydro-5,5,7,7-tetramethyl-2-[[(5-nitro-2-thienyl)carbonyl]amino]-thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester, NPC-26
• Empirical Formula (Hill Notation): C₁₉H₂₃N₃O₅S₂
• CAS Number: 864860-32-2
• Molecular Weight: 437.53
• NACRES: NA.77
• PubChem Substance ID: 329825516
• UNSPSC Code: 12352200
• MDL number: MFCD04428321
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: light orange to dark orange
• solubility: DMSO: 2 mg/mL, clear (warmed)
• storage temp.: 2-8°C
• SMILES string: CCOC(=O)c1c2CC(C)(C)NC(C)(C)c2sc1NC(=O)c3ccc(s3)[N+]([O-])=O
• InChI: 1S/C19H23N3O5S2/c1-6-27-17(24)13-10-9-18(2,3)21-19(4,5)14(10)29-16(13)20-15(23)11-7-8-12(28-11)22(25)26/h7-8,21H,6,9H2,1-5H3,(H,20,23)
• InChI key: DWGSXNATVAGHKZ-UHFFFAOYSA-N

Description

Biochem/physiol Actions

NPC26 induces mitochondrial fragmentation and cell death in RAS expressing cells, similar to erastin. The effects of NPC26 are independent of ROS scavengers, which can block cell death induced by erastin.

NPC26 induces mitochondrial fragmentation and cell death in RAS expressing cells.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable