SML0483

DpC

≥98% (HPLC)

• Synonym(s): Di-2-pyridylketone-4-cyclohexyl-4-methyl-3-thiosemicarbazone
• Empirical Formula (Hill Notation): C₁₉H₂₃N₅S
• CAS Number: 1382469-39-7
• Molecular Weight: 353.48
• NACRES: NA.77
• PubChem Substance ID: 329825434
• UNSPSC Code: 12352200
• MDL number: MFCD22666593
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: protect from light

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: protect from light
• color: white to beige
• solubility: DMSO: 5 mg/mL (clear solution)
• storage temp.: −20°C
• SMILES string: CN(C1CCCCC1)C(=S)N\N=C(\c2ccccn2)c3ccccn3
• InChI: 1S/C19H23N5S/c1-24(15-9-3-2-4-10-15)19(25)23-22-18(16-11-5-7-13-20-16)17-12-6-8-14-21-17/h5-8,11-15H,2-4,9-10H2,1H3,(H,23,25)
• InChI key: GNLZNQJBZNOUBM-UHFFFAOYSA-N

Description

Biochem/physiol Actions

DpC is an iron-chelating agent.

DpC is an iron-chelating agent. In four separate human pancreatic tumor cell lines, DpC significantly increased the expression and phosphorylation of the growth and metastasis suppressor, N-myc down-stream regulated gene 1 (NDRG1) and the cdk inhibitpr p21^CIP1/WAF. DpC completely blocked PANC-1 tumor growth in mouse xenografts.

Safety Information

• pictograms: GHS06
• signalword: Danger
• hcodes: H301
• pcodes: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable