SML0472

4-IPP

≥97% (HPLC)

• Synonym(s): 4-Iodo-6-phenylpyrimidine
• Empirical Formula (Hill Notation): C₁₀H₇IN₂
• CAS Number: 41270-96-6
• Molecular Weight: 282.08
• NACRES: NA.77
• PubChem Substance ID: 329825428
• UNSPSC Code: 12352200
• MDL number: MFCD00234609
• Assay: ≥97% (HPLC)
• Form: powder

Properties

• assay: ≥97% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 10 mg/mL (clear solution, warmed)
• storage temp.: −20°C
• SMILES string: Ic1cc(ncn1)-c2ccccc2
• InChI: 1S/C10H7IN2/c11-10-6-9(12-7-13-10)8-4-2-1-3-5-8/h1-7H
• InChI key: ZTCJXHNJVLUUMR-UHFFFAOYSA-N

Description

Application

4-IPP has been used as a macrophage migration inhibitory factor (MIF) in conditioned medium (CM) for in vitro migration assay.

Biochem/physiol Actions

4-IPP is a cell permeable, potent macrophage migration inhibitory factor (MIF) antagonist that covalently modifies MIF N-terminal proline.

4-IPP is a cell permeable, potent macrophage migration inhibitory factor (MIF) antagonist.

4-Iodo-6-phenylpyrimidine (4-IPP) has the potential to be a new anti-polyploid therapeutic agent that may be utilized in patients with thyroid cancer to target polyploid tumor cells. It suppresses osteoclastogenesis by blocking the IMF-κB pathway. 4-IPP can be employed as a therapeutic target for macrophage migration inhibitory factor (MIF) to treat pathologic osteolytic bone diseases and postmenopausal bone loss. It can prevent the development and motility of lung adenocarcinoma cells and can stimulate apoptosis and mitotic death of thyroid carcinomas.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3