SML0150

Tolcapone

≥98% (HPLC), Catechol-O-methyltransferase inhibitor, powder

• Synonym(s): 3,4-Dihydroxy-4′-methyl-5-nitrobenzophenone, Ro 40-7592
• Empirical Formula (Hill Notation): C₁₄H₁₁NO₅
• CAS Number: 134308-13-7
• Molecular Weight: 273.24
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825198
• NACRES: NA.77
• MDL number: MFCD00866569
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Properties

• Product Name: Tolcapone, ≥98% (HPLC)
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: yellow
• solubility: DMSO: ≥15 mg/mL
• originator: Roche
• storage temp.: 2-8°C
• SMILES string: Cc1ccc(cc1)C(=O)c2cc(O)c(O)c(c2)[N+]([O-])=O
• InChI: 1S/C14H11NO5/c1-8-2-4-9(5-3-8)13(17)10-6-11(15(19)20)14(18)12(16)7-10/h2-7,16,18H,1H3
• InChI key: MIQPIUSUKVNLNT-UHFFFAOYSA-N
• Gene Information: human ... COMT(1312)

Description

Application

Tolcapone may be used in COMT-mediated cell signaling studies.
Tolcapone has been used in methyltransferase assay in human embryonic kidney 293 cells.

Biochem/physiol Actions

Inhibition of catechol-O-methyltransferase by tolcapone increases the half-life and bioavailabilty of levodopa. It therefore is an effective adjunctive therapy in patients with Parkinson′s disease with motor response fluctuations.[1][2]

Orally active catechol-O-methyltransferase (COMT) inhibitor: inhibits both central and peripheral COMT.

Tolcapone is an orally active catechol-O-methyltransferase (COMT) inhibitor. It inhibits both central and peripheral COMT. Tolcapone crosses the blood-brain barrier, and has been used for L-DOPA adjunct therapy in the treatment of Parkinson′s Disease.

Features and Benefits

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• pictograms: GHS09
• signalword: Warning
• hcodes: H400
• pcodes: P273 - P391 - P501
• Hazard Classifications: Aquatic Acute 1
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable