SML0143

HC-067047

≥98% (HPLC), TRPV4 antagonist, powder

• Synonym(s): 2-Methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide
• Empirical Formula (Hill Notation): C₂₆H₂₈F₃N₃O₂
• CAS Number: 883031-03-6
• Molecular Weight: 471.51
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825191
• NACRES: NA.77
• MDL number: MFCD01571257
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Properties

• Product Name: HC-067047, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to tan
• solubility: DMSO: ≥15 mg/mL
• storage temp.: 2-8°C
• SMILES string: CC1=C(C(NC2=CC(C(F)(F)F)=CC=C2)=O)C=C(C3=CC=CC=C3)N1CCCN4CCOCC4
• InChI: 1S/C26H28F3N3O2/c1-19-23(25(33)30-22-10-5-9-21(17-22)26(27,28)29)18-24(20-7-3-2-4-8-20)32(19)12-6-11-31-13-15-34-16-14-31/h2-5,7-10,17-18H,6,11-16H2,1H3,(H,30,33)
• InChI key: NCZYSQOTAYFTNM-UHFFFAOYSA-N

Description

Application

HC-067047 has been used as a transient receptor potential cation channel subfamily V member 4 (TRPV4) inhibitor:

• to study its effects on organoid formation and proliferation in human endometrial tissues
• to determine its effects on neuronal survival after intracerebral hemorrhage (ICH)
• to study its effects on TRPV4 regulation of angiotensin II receptor type 1 (AT1R) task, phosphorylation and β-arrestin recruitment in choroid plexus

Biochem/physiol Actions

HC-067047 is a TRPV4 antagonist

HC-067047 is a potent, selective inhibitor of hTRPV4. The compound inhibits human, rat and mouse TRPV4 with IC₅₀ values of 48, 133 and 17 nM, respectively. HC-067047 does not inhibit other TRPV isoforms at concentrations up to 5 μM. HC-067047 inhibits hERG channel and the menthol receptor TRPM8 with IC₅₀ values of 370 and 780 nM, respectively.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable