SML0124

Rasagiline mesylate

≥98% (HPLC), MAO B inhibitor, powder

• Synonym(s): (1R)-2,3-Dihydro-N-2-propynl-1H-inden-1-amine methanesulfonate, N-Propargyl-1(R)-aminoindan methanesulfonate, TVP-1012
• Empirical Formula (Hill Notation): C₁₂H₁₃N · CH₄O₃S
• CAS Number: 161735-79-1
• Molecular Weight: 267.34
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825174
• NACRES: NA.77
• MDL number: MFCD08460604
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Properties

• Product Name: Rasagiline mesylate, ≥98% (HPLC)
• assay: ≥98% (HPLC)
• form: powder
• optical activity: [α]/D +15 to +28°, c = 0.6 mg/mL in H₂O
• storage condition: desiccated
• color: white to tan
• solubility: H₂O: ≥20 mg/mL
• storage temp.: 2-8°C
• SMILES string: CS(O)(=O)=O.C#CCN[C@@H]1CCc2ccccc12
• InChI: 1S/C12H13N.CH4O3S/c1-2-9-13-12-8-7-10-5-3-4-6-11(10)12;1-5(2,3)4/h1,3-6,12-13H,7-9H2;1H3,(H,2,3,4)/t12-;/m1./s1
• InChI key: JDBJJCWRXSVHOQ-UTONKHPSSA-N
• Gene Information: human ... MAOB(4129)

Description

Application

Rasagiline mesylate may be used in MAO type B-mediated cell signaling studies.

Rasagiline mesylate has been used:

• to test its neuroprotective effects in retinitis pigmentosa (RP) by apoptosis regulator, Bax/Bcl-2 modulation
• as monoamine oxidase-B inhibitor in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced mouse model
• as an anti-parkinsonian agent to test its rescue functionality in 6-hydroxydopamine-lesioned zebrafish larvae towards bradykinetic and dyskinetic-like behavior

Biochem/physiol Actions

Anti-Parkinson drug; MAO B Inhibitor; anti-apoptotic; neuroprotectant

Rasagiline mesylate is an effective therapeutic option in early stages of Parkinson′s disease. It improves the motor fluctuations in levodopa-treated patients and may be a useful adjunct to such patients. It has neuroprotective effects and increases the survival of dopaminergic neurons.

Rasagiline mesylate is an irreversible inhibitor of monoamine oxidase selective for MAO type B over type A by a factor of fourteen. It has anti-apoptotic and neuroprotectant activity and has been used as a treatment for Parkinson′s disease.

Features and Benefits

This compound is featured on the Dopamine and Norepinephrine Metabolism and Histamine Synthesis and Metabolism pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable