SML0034
1-EBIO
≥98% (HPLC)
Synonym(s):
1-Ethyl-1,3-dihydro-2H-benzimidazol-2-one; 1-Ethylbenzimidazolinone
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About This Item
Empirical Formula (Hill Notation):
C9H10N2O
CAS Number:
Molecular Weight:
162.19
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
233-148-1
MDL number:
Quality Level
assay
≥98% (HPLC)
form
powder
solubility
DMSO: ≥20 mg/mL
storage temp.
room temp
SMILES string
CCN1C(=O)Nc2ccccc12
InChI
1S/C9H10N2O/c1-2-11-8-6-4-3-5-7(8)10-9(11)12/h3-6H,2H2,1H3,(H,10,12)
InChI key
CXUCKELNYMZTRT-UHFFFAOYSA-N
Application
1-EBIO was used to study the electrical activity modulated by Ca+2-activated K+ channels in rat central neurons. The effect of 1-EBIO on human intermediate conductance channels was studied.
Biochem/physiol Actions
1-EBIO is an activator of epithelial Ca2+-activated K+ channel also known as the intermediate-conductance Ca(2+)-activated K(+) channel (IK-1) or KCa3.1.
1-EBIO is an activator of epithelial Ca2+-activated K+ channel
1-EBIO potentiates the secretion of CFTR-mediated Cl− ion secretion by activating the basolateral KCNN4 K+ channels in native human colonic tissues. It stimulates the apical Cl− channels and Ca+2-dependent basolateral K+ channels to stimulate fluid transport in lacrimal glands.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Audrey E Padula et al.
Translational psychiatry, 10(1), 414-414 (2020-11-29)
Mood disorders are often comorbid with alcohol use disorder (AUD) and play a considerable role in the development and maintenance of alcohol dependence and relapse. Because of this high comorbidity, it is necessary to determine shared and unique genetic factors
Eva K Roth et al.
PloS one, 6(8), e24445-e24445 (2011-09-13)
The identification of strategies to improve mutant CFTR function remains a key priority in the development of new treatments for cystic fibrosis (CF). Previous studies demonstrated that the K⁺ channel opener 1-ethyl-2-benzimidazolone (1-EBIO) potentiates CFTR-mediated Cl⁻ secretion in cultured cells
F Woodward Hopf et al.
Neuron, 65(5), 682-694 (2010-03-13)
The cellular mechanisms underlying pathological alcohol seeking remain poorly understood. Here, we show an enhancement of nucleus accumbens (NAcb) core action potential firing ex vivo after protracted abstinence from alcohol but not sucrose self-administration. Increased firing is associated with reduced
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML0034-10MG | 04061832575933 |
| SML0034-50MG | 04061832575940 |