S2196

Anti-Sodium Channel Na_V1.9 antibody produced in rabbit

affinity isolated antibody, lyophilized powder

• Synonym(s): Anti-NAN, Anti-SNS2
• MDL number: MFCD08705521
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 200
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: lyophilized powder
• species reactivity: rat
• technique(s): western blot: 1:200 using rat DRG lysates
• UniProt accession no.: O88457
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... SCN11A(11280) ; mouse ... Scn11a(24046) ; rat ... Scn11a(29701)

Description

General description

Sodium Channel NaV1.9 is a threshold channel, that is expressed in dorsal root ganglion neurons , peripheral nociceptive neurons and visceral afferents. It is also called as SNS and NaN. It is encoded by SCN11A (sodium voltage-gated channel subunit 11) and is located on human chromosome 3p22.

Immunogen

peptide CNGDLSSLDVAKVKVHND corresponding to residues 1748-1765 of rat Na_v1.9. This sequence has 15/18 residues identical in mouse and 14/18 residues identical in human.

Biochem/physiol Actions

Sodium Channel NaV1.9 participates in pain at the time of inflammation. Downregulation of Nav1.9 is observed in Hirschsprung′s disease.

Physical form

Lyophilized from phosphate buffered saline, pH 7.4, with 1% bovine serum albumin, and 0.05% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable