This material includes a proprietary 20 amino acids tag before the first Met. The calculated molecular weight is not available. However, in SDS-PAGE gels, this product runs at approximately 15 - 20 kDa as shown below.
S1071
α-Synuclein A53T human
recombinant, expressed in E. coli, N-terminal histidine tagged, ≥90% (SDS-PAGE), lyophilized powder
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About This Item
Pricing and availability is not currently available.
recombinant
expressed in E. coli
Quality Segment
assay
≥90% (SDS-PAGE)
form
lyophilized powder
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Gene Information
human ... SNCA(6622)
General description
Application
α-Synuclein A53T human has been used to treat mesencephalic neuronal and stimulate microglial cells prior to reactive oxygen species (ROS) measurement, immunohistochemistry and imaging studies.[3]
Biochem/physiol Actions
α-Synuclein (α-Syn) interacts with toll-like receptor 2 (TLR2) and mediates interleukin-1β (IL-1β) synthesis.[3]
A point mutation in the α-synuclein gene, A53T (Ala53-Thr), is linked to familial Parkinson′s disease.
A point mutation in the α-synuclein gene, A53T (Ala53-Thr), is linked to familial Parkinson′s disease. Mice expressing A53T human α-synuclein, but not wild-type or the A30P variants, develop adult-onset neurodegenerative disease with a progressive motoric dysfunction leading to death.
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This Item | |||
|---|---|---|---|
| recombinant expressed in E. coli | recombinant expressed in E. coli | recombinant - | recombinant - |
| assay ≥90% (SDS-PAGE) | assay ≥90% (SDS-PAGE) | assay >95% (gel scan and mass spectrometry) | assay >95% (SDS-PAGE) |
| Quality Level 200 | Quality Level 200 | Quality Level 100 | Quality Level 100 |
| form lyophilized powder | form lyophilized powder | form solid | form powder |
| Gene Information human ... SNCA(6622) | Gene Information human ... SNCA(6622) | Gene Information human ... SNCA(6622) | Gene Information human ... SNCA(6622) |
| UniProt accession no. | UniProt accession no. | UniProt accession no. | UniProt accession no. |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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what is it molecular weight?
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