P9528
Polyuridylic acid potassium salt
Synonym(s):
Poly(U) potassium salt
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About This Item
Assay:
≥98% (TLC)
Form:
lyophilized powder
Solubility:
water: 19.60-20.40 mg/mL, clear to slightly hazy, colorless
Storage temp.:
−20°C
assay
≥98% (TLC)
Quality Level
form
lyophilized powder
solubility
water: 19.60-20.40 mg/mL, clear to slightly hazy, colorless
storage temp.
−20°C
SMILES string
[P](=O)(OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)[n]2[c]([nH][c](cc2)=O)=O)(O)O
InChI
1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
InChI key
DJJCXFVJDGTHFX-XVFCMESISA-N
Application
Polyuridylic acid (Poly(U)), a homopolymer of uridine, is used as a single-stranded RNA model compound often in comparison with other ssRNA model oligonucleotides such as Poly(I) and Poly(C) to study processes that are dependent upon ssRNA regulation such as Toll-like receptor regulation. Poly(U) is used as an effective agonist for TLR7.
Preparation Note
Prepared from UDP using polynucleotide phosphorylase.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Soren Nielsen et al.
Science (New York, N.Y.), 340(6140), 1577-1580 (2013-07-03)
Gene expression in organisms involves many factors and is tightly controlled. Although much is known about the initial phase of transcription by RNA polymerase III (Pol III), the enzyme that synthesizes the majority of RNA molecules in eukaryotic cells, termination
Tiago Antonio de Souza et al.
PloS one, 7(2), e32305-e32305 (2012-03-03)
Plant pathogenic bacteria utilize an array of effector proteins to cause disease. Among them, transcriptional activator-like (TAL) effectors are unusual in the sense that they modulate transcription in the host. Although target genes and DNA specificity of TAL effectors have
Liam M Longo et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(27), 15731-15739 (2020-06-21)
De novo emergence demands a transition from disordered polypeptides into structured proteins with well-defined functions. However, can polypeptides confer functions of evolutionary relevance, and how might such polypeptides evolve into modern proteins? The earliest proteins present an even greater challenge
A Maxwell Burroughs et al.
Nucleic acids research, 40(4), 1424-1437 (2011-11-08)
Recent research hints at an underappreciated complexity in pre-miRNA processing and regulation. Global profiling of pre-miRNA and its potential to increase understanding of the pre-miRNA landscape is impeded by overlap with highly expressed classes of other non coding (nc) RNA.
Adrian C Barbrook et al.
Plant molecular biology, 79(4-5), 347-357 (2012-05-09)
Although transcription and transcript processing in the chloroplasts of plants have been extensively characterised, the RNA metabolism of other chloroplast lineages across the eukaryotes remains poorly understood. In this paper, we use RT-PCR to study transcription and transcript processing in
Global Trade Item Number
| SKU | GTIN |
|---|---|
| P9528-100MG | 04061834403555 |
| P9528-10MG | 04061833289990 |
| P9528-25MG | 04061833290002 |
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